2-tert-Butyl-4-methylphenol
2-tert-Butyl-4-methylphenol structure
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Common Name | 2-tert-Butyl-4-methylphenol | ||
|---|---|---|---|---|
| CAS Number | 2409-55-4 | Molecular Weight | 164.244 | |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 237.0±0.0 °C at 760 mmHg | |
| Molecular Formula | C11H16O | Melting Point | 50-52 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 100.0±0.0 °C | |
| Symbol |
GHS05, GHS09 |
Signal Word | Danger | |
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Cellular apoptosis and cytotoxicity of phenolic compounds: a quantitative structure-activity relationship study.
J. Med. Chem. 48 , 7234-42, (2005) In this comprehensive study on the caspase-mediated apoptosis-inducing effect of 51 substituted phenols in a murine leukemia cell line (L1210), we determined the concentrations needed to induce caspase activity by 50% (I50) and utilized these data to develop ... |
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Pharmacological actions of thymol and an analogue at GABAB autoreceptors.
Clin. Exp. Pharmacol. Physiol. 41(9) , 623-7, (2014) GABAB autoreceptors inhibit release of GABA from GABAergic nerve terminals. Agonists of these receptors (e.g. baclofen) inhibit, whereas antagonists (e.g. (+)-(S)-5,5-dimethylmorpholinyl-2-acetic acid; Sch 50911) enhance release of the transmitter. The action... |
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Role of free radicals in the mode of action of anthralin.
Skin Pharmacol. 1(2) , 115-21, (1988) Radical reactions of anthralin and its metabolites with skin have been studied by ESR spectroscopy. The influence of compounds which are known to suppress inflammation are described. The ESR spectra recorded during the reaction of anthralin with skin were ess... |
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Modification of N-methyl-N'-nitro-N-nitrosoguanidine-induced forestomach and glandular stomach carcinogenesis by phenolic antioxidants in rats.
Cancer Res. 48(18) , 5310-5, (1988) The modifying effects of five phenolic antioxidants on N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-initiated forestomach and glandular stomach carcinogenesis were investigated in male F344 rats. Groups of 20 rats were given an intragastric dose of 150 mg/kg b... |
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Effects of subsequent antioxidant treatment on 7,12-dimethylbenz[a]anthracene-initiated carcinogenesis of the mammary gland, ear duct and forestomach in Sprague-Dawley rats.
Carcinogenesis 9(1) , 101-4, (1988) The effects of the antioxidants tetramethyl-p-phenylenediamine (TMPD), propyl gallate (PG), quercetin (QC), 2-tert-butyl-4-methylphenol (TBMP), tert-butylhydroquinone (TBHQ), 3,3'-thiodipropionic acid (TDPA), guaiac gum (GG) and caffeic acid (CA) on 7,12-dime... |
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Free radical intermediates during peroxidase oxidation of 2-t-butyl-4-methoxyphenol, 2,6-di-t-butyl-4-methylphenol, and related phenol compounds.
Arch. Biochem. Biophys. 269(2) , 423-32, (1989) 2-t-butyl-4-methoxyphenol (BHA) and 2,6-di-t-butyl-4-methylphenol (BHT) are widely used antioxidant food additives that are generally recognized as safe by the Food and Drug Administration. Previously reported studies have suggested that the ip LD50 of BHA ma... |
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Structure-activity relations in promotion of rat urinary bladder carcinogenesis by phenolic antioxidants.
Jpn. J. Cancer Res. 81(8) , 754-9, (1990) The urinary bladder tumor-promoting potentials of the phenolic antioxidants, 2-tert-butyl-4-methylphenol (TBMP), propylparaben, catechol, resorcinol and hydroquinone, which are structurally related to butylated hydroxyanisole (BHA), were investigated in 170 m... |
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Effects of phenolic antioxidants in low dose combination on forestomach carcinogenesis in rats pretreated with N-methyl-N'-nitro-N-nitrosoguanidine.
Cancer Res. 51(3) , 824-7, (1991) The combined effects of low doses of promoters or carcinogens on two-stage forestomach carcinogenesis were examined in rats pretreated with N-methyl-N'-nitro-N-nitrosoguanidine. Groups of 15 rats were given a single 150 mg/kg body weight intragastric dose of ... |
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Early proliferative responses of forestomach and glandular stomach of rats treated with five different phenolic antioxidants.
Carcinogenesis 11(3) , 425-9, (1990) The effects of 8 weeks of oral administration of five different phenolic antioxidants, e.g. catechol (CC), resorcinol, hydroquinone (HQ), 2-tert-butyl-4-methylphenol (TBMP) and propylparabene (PP), on forestomach and glandular stomach epithelium of male F344 ... |
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Interaction of 1-hydroxyethyl radical with antioxidant enzymes.
Arch. Biochem. Biophys. 372(2) , 355-9, (1999) There is considerable interest in the role of the 1-hydroxyethyl radical (HER) in the toxic effects of ethanol. The goal of this study was to evaluate the effects of HER on classical antioxidant enzymes. The interaction of acetaldehyde with hydroxylamine-o-su... |