7-Acetoxy-4-methylcoumarin
7-Acetoxy-4-methylcoumarin structure
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Common Name | 7-Acetoxy-4-methylcoumarin | ||
|---|---|---|---|---|
| CAS Number | 2747-05-9 | Molecular Weight | 218.20500 | |
| Density | 1.263g/cm3 | Boiling Point | 371.4ºC at 760mmHg | |
| Molecular Formula | C12H10O4 | Melting Point | 149-150 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 191.5ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Automated carboxylesterase assay for the evaluation of ionic liquids' human toxicity.
J. Hazard. Mater. 244-245 , 563-9, (2013) Aiming the prediction of ionic liquids' (ILs) human toxicity, an automated carboxylesterase activity assay was developed. The method was implemented on a sequential injection analysis (SIA) system and relied on the hydrolysis of 4-methylumbelliferyl acetate b... |
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Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases.
J. Med. Chem. 48 , 2906-15, (2005) Carboxylesterases (CE) are ubiquitous enzymes responsible for the metabolism of xenobiotics. Because the structural and amino acid homology among esterases of different classes, the identification of selective inhibitors of these proteins has proved problemat... |
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Comparison of xenobiotic metabolizing enzyme activities in ex vivo human skin and reconstructed human skin models from SkinEthic.
Arch. Toxicol. 88(9) , 1681-1694, (2014) Skin function is not limited to a physical barrier. According to its total surface area, it is also considered as an extra-hepatic metabolizing organ. In vitro engineered human skins have been developed to replace limited ex vivo normal human skin samples (NH... |
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Specificity of procaine and ester hydrolysis by human, minipig, and rat skin and liver.
Drug Metab. Dispos. 35(11) , 2015-22, (2007) The capacity of human, minipig, and rat skin and liver subcellular fractions to hydrolyze the anesthetic ester procaine was compared with carboxylesterase substrates 4-methylumbelliferyl-acetate, phenylvalerate, and para-nitrophenylacetate and the arylesteras... |
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Latent blue and red fluorophores based on the trimethyl lock.
ChemBioChem. 7(8) , 1151-4, (2006)
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Ligand exclusion on acetylcholinesterase.
Biochemistry 29(47) , 10640-9, (1990) This paper examines covalent reactivity of AchE with respect to cationic and uncharged methylphosphonates and substrates in the absence and presence of cationic ligands selective for the active center and the peripheral anionic site. The organophosphorus inhi... |
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Specificities of calreticulin transacetylase to acetoxy derivatives of 3-alkyl-4-methylcoumarins: effect on the activation of nitric oxide synthase.
Bioorg. Med. Chem. 17 , 1550-6, (2009) Calreticulin Transacetylase (CRTAase) catalyzes the transfer of acetyl groups from polyphenolic acetates (PAs) to the receptor proteins and modulates their biological activities. CRTAase was conveniently assayed by the irreversible inhibition of cytosolic glu... |
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Comparative specificities of Calreticulin Transacetylase to O-acetyl, N-acetyl and S-acetyl derivative of 4-methylcoumarins and their inhibitory effect on AFB1-induced genotoxicity in vitro and in vivo.
Food Chem. Toxicol. 52 , 216-24, (2013) We have earlier conclusively established the Calreticulin Transacetylase (CRTAase) catalyzed modifications of functional proteins such as cytochrome-P450-linked mixed function oxidases (Cyt-P450-linked MFOs), NADPH cytochrome c reductase, and glutathione S-tr... |
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Specificities of acetoxy derivatives of coumarins, biscoumarins, chromones, flavones, isoflavones and xanthones for acetoxy drug: protein transacetylase.
Eur. J. Med. Chem. 42 , 447-55, (2007) The earlier work carried out in our laboratory led to the identification of a novel rat liver microsomal enzyme termed as acetoxy drug: protein transacetylase (TAase), catalyzing the transfer of acetyl group from polyphenolic acetates (PA) to functional prote... |
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Functional characterization of three naturally occurring single nucleotide polymorphisms in the CES2 gene encoding carboxylesterase 2 (HCE-2).
Drug Metab. Dispos. 33(10) , 1482-7, (2005) Twelve single nucleotide polymorphisms (SNPs) in the human CES2 gene, which encodes a carboxylesterase, hCE-2 [human carboxylesterase 2 (EC 3.1.1.1)], have been reported in the Japanese. In this report, we have examined functional alterations of three SNPs, a... |