N,N'-Dicyclohexyl-4-morpholinecarboxamidine
N,N'-Dicyclohexyl-4-morpholinecarboxamidine structure
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Common Name | N,N'-Dicyclohexyl-4-morpholinecarboxamidine | ||
|---|---|---|---|---|
| CAS Number | 4975-73-9 | Molecular Weight | 293.448 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 423.2±55.0 °C at 760 mmHg | |
| Molecular Formula | C17H31N3O | Melting Point | 105-107 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 209.7±31.5 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Enhanced inhibition of orthopoxvirus replication in vitro by alkoxyalkyl esters of cidofovir and cyclic cidofovir.
Antimicrob. Agents Chemother. 46(4) , 991-5, (2002) The nucleotide phosphonates cidofovir (CDV) and cyclic cidofovir (cCDV) are potent antiviral compounds when administered parenterally but are not well absorbed orally. These compounds have been reported to have activity against orthopoxvirus replication in vi... |
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Synthesis and diuretic activity of alkyl- and arylguanidine analogs of N,N'-dicyclohexyl-4-morpholinecarboxamidine in rats and dogs.
J. Med. Chem. 37(22) , 3693-700, (1994) Random screening identified N,N'-dicyclohexyl-4-morpholinecarboxamidine (U-18177, 1) as an orally effective nonkaliuretic diuretic in rats. The diuretic profile of 1 and its 1-adamantyl analog (U-37883A, 4) was confirmed orally in dogs, when they were less po... |
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An ATP-sensitive potassium channel blocker suppresses sodium-induced hypertension through increased secretion of urinary kallikrein.
Hypertens. Res. 32(3) , 220-6, (2009) It is suggested that an ATP-sensitive potassium channel blocker suppresses sodium-induced hypertension through increased secretion of urinary kallikrein. We reported that glibenclamide, an ATP-sensitive potassium channel blocker, accelerated dose-dependent se... |