L-685,458
L-685,458 structure
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Common Name | L-685,458 | ||
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| CAS Number | 292632-98-5 | Molecular Weight | 672.85300 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C39H52N4O6 | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
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RAGE inhibition in microglia prevents ischemia-dependent synaptic dysfunction in an amyloid-enriched environment.
J. Neurosci. 34(26) , 8749-60, (2014) Ischemia is known to increase the deleterious effect of β-amyloid (Aβ), contributing to early cognitive impairment in Alzheimer's disease. Here, we investigated whether transient ischemia may function as a trigger for Aβ-dependent synaptic impairment in the e... |
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Suppression of Notch signaling in the neonatal mouse ovary decreases primordial follicle formation.
Endocrinology 150 , 1014-24, (2009) Notch signaling directs cell fate during embryogenesis by influencing cell proliferation, differentiation, and apoptosis. Notch genes are expressed in the adult mouse ovary, and roles for Notch in regulating folliculogenesis are beginning to emerge from mouse... |
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L-685,458, an aspartyl protease transition state mimic, is a potent inhibitor of amyloid beta-protein precursor gamma-secretase activity.
Biochemistry 39 , 8698, (2000) Progressive cerebral amyloid beta-protein (A beta) deposition is believed to play a central role in the pathogenesis of Alzheimer's disease (AD). Elevated levels of A beta(42) peptide formation have been linked to early-onset familial AD-causing gene mutation... |