Amiodarone HCl
Amiodarone HCl structure
|
Common Name | Amiodarone HCl | ||
|---|---|---|---|---|
| CAS Number | 19774-82-4 | Molecular Weight | 681.773 | |
| Density | 1.58 g/cm3 | Boiling Point | 635.1ºC at 760 mmHg | |
| Molecular Formula | C25H30ClI2NO3 | Melting Point | 154-158°C | |
| MSDS | Chinese USA | Flash Point | 337.9ºC | |
| Symbol |
GHS02, GHS06, GHS08 |
Signal Word | Danger | |
|
In Vitro Multiparameter Assay Development Strategy toward Differentiating Macrophage Responses to Inhaled Medicines.
Mol. Pharm. 12 , 2675-87, (2015) Although foamy macrophages (FMΦ) are commonly observed during nonclinical development of medicines for inhalation, there are no accepted criteria to differentiate adaptive from adverse FMΦ responses in drug safety studies. The purpose of this study was to dev... |
|
|
Quality evaluation and pattern recognition analyses of bioactive marker compounds from Farfarae Flos using HPLC/PDA.
Chem. Pharm. Bull. 63 , 546-53, (2015) The flower bud of Tussilago farfara L., called Farfarae Flos, has traditionally been used in Oriental medicine for the treatment of bronchitis and asthma. To establish a standard for quality control as well as the reliable identification of Farfarae Flos, the... |
|
|
High-Content Assay Multiplexing for Toxicity Screening in Induced Pluripotent Stem Cell-Derived Cardiomyocytes and Hepatocytes.
Assay Drug Dev. Technol. 13 , 529-46, (2015) Cell-based high-content screening (HCS) assays have become an increasingly attractive alternative to traditional in vitro and in vivo testing in pharmaceutical drug development and toxicological safety assessment. The time- and cost-effectiveness of HCS assay... |
|
|
Multiparametric assay using HepaRG cells for predicting drug-induced liver injury.
Toxicol. Lett. 236 , 16-24, (2015) The utility of HepaRG cells as an in vitro cell-based assay system for assessing drug-induced liver injury (DILI) risk was investigated. Seventeen DILI-positive and 15 DILI-negative drugs were selected for the assay. HepaRG cells were treated with each drug f... |
|
|
Embolization of the first diagonal branch of the left anterior descending coronary artery as a porcine model of chronic trans-mural myocardial infarction.
J. Transl. Med. 13 , 187, (2015) Although the incidence of acute death related to coronary artery disease has decreased with the advent of new interventional therapies, myocardial infarction remains one of the leading causes of death in the US. Current animal models developed to replicate th... |
|
|
A live zebrafish-based screening system for human nuclear receptor ligand and cofactor discovery.
PLoS ONE 5 , e9797, (2010) Nuclear receptors (NRs) belong to a superfamily of transcription factors that regulate numerous homeostatic, metabolic and reproductive processes. Taken together with their modulation by small lipophilic molecules, they also represent an important and success... |
|
|
Antiarrhythmic efficacy of CPUY102122, a multiple ion channel blocker, on rabbits with ischemia/reperfusion injury.
Pharmacol. Rep. 66(6) , 1022-30, (2014) The antiarrhythmic potential of a novel multichannel blocker CPUY102122 (CY22) was investigated in the present study.The effect of CY22 on rapid delayed rectifier potassium channel current (IKr) was studied using whole-cell patch clamp techniques in Chinese H... |
|
|
In vitro thyroid disrupting effects of organic extracts from WWTPs in Beijing.
J. Environ. Sci. (China) 23 , 671-5, (2011) It is generally known that there are many endocrine disrupting compounds (EDCs) in the effluents from wastewater treatment plants (WWTPs). Most research has focused on the occurrence of estrogenic or androgenic activities, while ignoring that there are enviro... |