5-Iodocytosine
5-Iodocytosine structure
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Common Name | 5-Iodocytosine | ||
|---|---|---|---|---|
| CAS Number | 1122-44-7 | Molecular Weight | 236.999 | |
| Density | 2.7±0.1 g/cm3 | Boiling Point | 480.2ºC at 760mmHg | |
| Molecular Formula | C4H4IN3O | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 244.2ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Enzymatic primer-extension with glycerol-nucleoside triphosphates on DNA templates.
PLoS ONE 4(3) , e4949, (2009) Glycerol nucleic acid (GNA) has an acyclic phosphoglycerol backbone repeat-unit, but forms stable duplexes based on Watson-Crick base-pairing. Because of its structural simplicity, GNA is of particular interest with respect to the possibility of evolving func... |
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Preparation and properties of oligodeoxynucleotides containing 5-iodouracil and 5-bromo- and 5-iodocytosine.
Bioconjug. Chem. 8(5) , 757-61, (1997) The behavior of oligonucleotides containing 5-iodouracil, 5-bromocytidine, and 5-iodocytidine in concentrated ammonia is described. 5-Aminouracil and 5-aminocytidine are obtained as side products when deprotection is performed at 60 degrees C. Small amounts, ... |
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Photochemistry of halogen pyrimidines: iodine release studies.
Photochem. Photobiol. 56(1) , 9-15, (1992) The feasibility of using direct iodide (I-) measurements to monitor the photochemistry of the halogenated pyrimidines 5-iodocytosine and 5-iodouracil and their corresponding deoxynucleosides was examined. Radiation from either a germicidal lamp (lambda = 254 ... |
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Synthesis and biological activities of 2'-deoxy-2'-fluoro-4'-thioarabinofuranosylpyrimidine and -purine nucleosides.
Bioorg. Med. Chem. 8 , 1545-1558, (2000) As part of our ongoing investigation of the synthesis of biologically interesting 2'-modified-4'-thionucleosides, we synthesized 2'-deoxy-2'-fluoro-4'-thioarabinofuranosylpyrimidine and -purine nucleosides, and evaluated their antiviral and antitumor activiti... |
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Nucleobase modified peptide nucleic acid.
Nucleosides Nucleotides Nucleic Acids 22 , 1029-1033, (2003) The Pd0/Cu1 catalyzed cross-coupling of terminal alkynes onto peptide nucleic acid monomers or submonomers bearing iodinated nucleobases has been utilized as a route to base-modified oligomers. Both 5-iodouracil and 5-iodocytosine derivatives undergo the cros... |
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A direct synthesis of pyrrolocytosine from 5-iodocytosine.
Nucleosides Nucleotides Nucleic Acids 24 , 581-584, (2005) We have employed a tandem Sonogashira/annulation reaction between 5-iodocytosine derivatives and terminal alkynes to yield the fluorescent bicyclic nucleobase pyrrolcytosine. Pyrrolocytosine bearing substituents only on the pyrrole ring are conveniently synth... |
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Mapping features of HIV-1 integrase near selected sites on viral and target DNA molecules in an active enzyme-DNA complex by photo-cross-linking.
Biochemistry 36(35) , 10655-65, (1997) The virally encoded integrase protein carries out retroviral integration, and to do so, it must make specific interactions with both viral and target DNA sequences. The retroviral integrase has three domains: an amino-terminal region of about 50 amino acids t... |
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Mouse RS21-C6 is a mammalian 2'-deoxycytidine 5'-triphosphate pyrophosphohydrolase that prefers 5-iodocytosine.
FEBS J. 276(6) , 1654-66, (2009) Free nucleotides in living cells play important roles in a variety of biological reactions, and often undergo chemical modifications of their base moieties. As modified nucleotides may have deleterious effects on cells, they must be eliminated from intracellu... |
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The GTP-dependent restriction enzyme McrBC from Escherichia coli forms high-molecular mass complexes with DNA and produces a cleavage pattern with a characteristic 10-base pair repeat.
Biochemistry 41(16) , 5245-54, (2002) The GTP-dependent restriction enzyme McrBC consists of two polypeptides: one (McrB) that is responsible for GTP binding and hydrolysis as well as DNA binding and another (McrC) that is responsible for DNA cleavage. It recognizes two methylated or hemimethylat... |
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Condensation of nucleobases at mercury/aqueous solution interface--a structural perspective using hydrogen bonding considerations.
J. Colloid. Interface Sci. 250(1) , 201-12, (2002) The two-dimensional condensation behavior exhibited by nucleobases at a mercury/aqueous solution interface is analyzed on the basis of their hydrogen-bonded quadruplex structures, and the experimentally observed critical temperatures are rationalized incorpor... |