Mexiletine hydrochloride
Mexiletine hydrochloride structure
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Common Name | Mexiletine hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 5370-01-4 | Molecular Weight | 215.720 | |
| Density | 0.979 g/cm3 | Boiling Point | 271.5ºC at 760 mmHg | |
| Molecular Formula | C11H18ClNO | Melting Point | 200-203°C | |
| MSDS | Chinese USA | Flash Point | 112.2ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Developing structure-activity relationships for the prediction of hepatotoxicity.
Chem. Res. Toxicol. 23 , 1215-22, (2010) Drug-induced liver injury is a major issue of concern and has led to the withdrawal of a significant number of marketed drugs. An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification o... |
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A predictive ligand-based Bayesian model for human drug-induced liver injury.
Drug Metab. Dispos. 38 , 2302-8, (2010) Drug-induced liver injury (DILI) is one of the most important reasons for drug development failure at both preapproval and postapproval stages. There has been increased interest in developing predictive in vivo, in vitro, and in silico models to identify comp... |
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Chemical genetics reveals a complex functional ground state of neural stem cells.
Nat. Chem. Biol. 3(5) , 268-273, (2007) The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways ... |
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Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
Nat. Chem. Biol. 5 , 765-71, (2009) Studies of gene function and molecular mechanisms in Plasmodium falciparum are hampered by difficulties in characterizing and measuring phenotypic differences between individual parasites. We screened seven parasite lines for differences in responses to 1,279... |
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Cardioprotective effects of sarcolemmal and mitochondrial K-ATP channel openers in an experimental model of autoimmune myocarditis. Role of the reduction in calcium overload during acute heart failure.
Int. Heart J. 53(2) , 139-45, (2012) It has been reported that K-ATP channel openers have a cardioprotective effect in acute ischemia as a pharmacological preconditioning effect. In the present study, the chronic effects of clinical K-ATP channel openers, ie, nicorandil (Nic) and mexiletine (Mex... |
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Detecting drug-induced prolongation of the QRS complex: New insights for cardiac safety assessment
Toxicol. Appl. Pharmacol. 265(2) , 200-8, (2012) Background Drugs slowing the conduction of the cardiac action potential and prolonging QRS complex duration by blocking the sodium current (INa) may carry pro-arrhythmic risks. Due to the frequency-dependent block of INa, this study assesses whether activity-... |
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Induced pluripotent stem cells used to reveal drug actions in a long QT syndrome family with complex genetics.
J. Gen. Physiol. 141(1) , 61-72, (2013) Understanding the basis for differential responses to drug therapies remains a challenge despite advances in genetics and genomics. Induced pluripotent stem cells (iPSCs) offer an unprecedented opportunity to investigate the pharmacology of disease processes ... |
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Etodolac, a cyclooxygenase-2 inhibitor, attenuates paclitaxel-induced peripheral neuropathy in a mouse model of mechanical allodynia.
J. Pharmacol. Exp. Ther. 342(1) , 53-60, (2012) The effect of the cyclooxygenase-2 (COX-2) inhibitor etodolac on the mechanical allodynia induced by paclitaxel was investigated in mice and compared with the effects of the nonselective COX inhibitors indomethacin and diclofenac, the selective COX-2 inhibito... |
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Wide QRS Tachycardia in a young patient.
Arch. Intern. Med. 172(7) , 537; discussion 538-9, (2012)
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Inhibition of late sodium current by mexiletine: a novel pharmotherapeutical approach in timothy syndrome.
Circ. Arrhythm. Electrophysiol. 6(3) , 614-22, (2013) Timothy syndrome (TS) is a rare long-QT syndrome caused by CACNA1C mutations G406R in exon 8A (TS1) and G402S/G406R in exon 8 (TS2). Management of TS is a challenge and prognosis is poor. This study aimed to explore the inheritance pattern and mechanism of an... |