Bromadiolone
Bromadiolone structure
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Common Name | Bromadiolone | ||
|---|---|---|---|---|
| CAS Number | 28772-56-7 | Molecular Weight | 527.405 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 723.4±60.0 °C at 760 mmHg | |
| Molecular Formula | C30H23BrO4 | Melting Point | 200-210ºC | |
| MSDS | Chinese USA | Flash Point | 391.3±32.9 °C | |
| Symbol |
GHS06, GHS09 |
Signal Word | Danger | |
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Risk of combined exposure of birds to cyanobacterial biomass containing microcystins, acetylcholinesterase inhibitor and anticoagulant.
Neuro Endocrinol. Lett. 33 Suppl 3 , 155-60, (2012) The objective of this study was to examine the hypothesis that a combination of cyanobacterial biomass containing microcystins, acetylcholinesterase inhibitor and anticoagulant can enhance avian toxic effects produced by single exposures only.A total of 48 tw... |
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[Determination of five 4-hydroxycoumarin rodenticides in whole blood by high performance liquid chromatography with fluorescence detection].
Se Pu 25(2) , 214-6, (2007) A simple, accurate and sensitive method has been developed for the simultaneous determination of warfarin, coumatetralyl, bromadiolone, flocoumafen and brodifacoum in whole blood by high performance liquid chromatography (HPLC) with fluorescence detection. Th... |
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Bromadiolone susceptibility in wild and laboratory Mus musculus L.(house mice) in Buenos Aires, Argentina.
Pest Manag. Sci. 66(2) , 162-7, (2010) Rodents are major pests in many agricultural systems, where they can cause significant economic losses and involve a sanitary risk. The application of anticoagulant rodenticides for rodent control has showed a decrease in effectiveness through time because of... |
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Are water vole resistant to anticoagulant rodenticides following field treatments?
Ecotoxicology 20(6) , 1432-41, (2011) The anti-vitamin Ks (AVKs) are widely used to control rodent populations. They inhibit Vitamin K regeneration by the Vitamin K Epoxide Reductase (VKOR) and cause a fatal hemorrhagic syndrome. Because of repeated use, some populations of commensal rodents have... |
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Vitamin K requirement and reproduction in bromadiolone-resistant Norway rats.
Pest Manag. Sci. 68(3) , 378-85, (2012) Nucleotide polymorphisms in the VKORC1 gene can be linked to anticoagulant rodenticide resistance in Norway rats (Rattus norvegicus Berkenhout). This provides a fitness advantage to rats exposed to anticoagulant actives, but may also cause fitness costs. The ... |
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Bromadiolone toxicokinetics: diagnosis and treatment implications.
Clin. Toxicol. (Phila.) 46(8) , 703-10, (2008) Ingestion of bromadiolone can lead to prolonged and life-threatening coagulopathy. Traditional treatment of bromadiolone intoxication relies on the coagulation profile. Currently, there is scanty information on bromadiolone elimination kinetics and half-life.... |
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Characterization of bromadiolone resistance in a danish strain of Norway rats, Rattus norvegicus, by hepatic gene expression profiling of genes involved in vitamin K-dependent gamma-carboxylation.
J. Biochem. Mol. Toxicol. 21(6) , 373-81, (2007) The present study characterizes the anticoagulant resistance mechanism in a Danish bromadiolone-resistant strain of Norway rats (Rattus norvegicus), with a Y139C VKORC1 mutation. We compared liver expression of the VKORC1 gene, which encodes a protein of the ... |
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Bromadiolone poisoning: LC-MS method and pharmacokinetic data.
J. Forensic Sci. 53(4) , 993-6, (2008) Poisoning with superwarfarins, like bromadiolone, is a growing public health problem, and the mortality is high. Pharmacokinetic data on bromadiolone in humans are however scarce, and there are no reports following repeated exposures to bromadiolone. We have ... |
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Determination of bromadiolone and brodifacoum in human hair by liquid chromatography/tandem mass spectrometry and its application to poisoning cases.
Rapid Commun. Mass Spectrom. 27(4) , 513-20, (2013) Bromadiolone and brodifacoum, two common anticoagulant rodenticides, are involved in the majority of anticoagulant rodenticide poisoning cases in humans in China. Hair analysis can provide long-term information on drug exposure. A method using liquid chromato... |
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An HPLC method for the determination of bromadiolone plasma kinetics and its residues in hen eggs.
J. Chromatogr. Sci. 48(9) , 714-20, (2010) Cereal-based bromadiolone anticoagulant is often used for rodent control, and because these baits are attractive for poultry they may be accidentally ingested. Thus, the aim of this study was to develop a new high-performance liquid chromatography (HPLC) meth... |