(R,S)-Norcotinine
(R,S)-Norcotinine structure
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Common Name | (R,S)-Norcotinine | ||
|---|---|---|---|---|
| CAS Number | 17708-87-1 | Molecular Weight | 162.189 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 398.2±35.0 °C at 760 mmHg | |
| Molecular Formula | C9H10N2O | Melting Point | 108-109ºC | |
| MSDS | N/A | Flash Point | 194.6±25.9 °C | |
| Symbol |
GHS02, GHS06, GHS08 |
Signal Word | Danger | |
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Determination of nicotine and four metabolites in the serum of smokers by high-performance liquid chromatography with ultraviolet detection.
J. Chromatogr. A. 621(2) , 257-61, (1993) A simple and reliable reversed-phase high-performance liquid chromatographic method with ultraviolet detection is described for the quantitation of nicotine and its metabolites cotinine, trans-3'-hydroxycotinine, norcotinine and cotinine N-oxide in human seru... |
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Meconium nicotine and metabolites by liquid chromatography-tandem mass spectrometry: differentiation of passive and nonexposure and correlation with neonatal outcome measures.
Clin. Chem. 54(12) , 2018-27, (2008) Meconium analysis is a diagnostically sensitive and objective alternative to maternal self-report for detecting prenatal tobacco exposure. Nicotine and metabolite disposition in meconium is poorly characterized, and correlation of analytes' concentrations wit... |
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Quantification of nicotine, cotinine, trans-3'-hydroxycotinine, nornicotine and norcotinine in human meconium by liquid chromatography/tandem mass spectrometry.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 863(1) , 107-14, (2008) There are no analytical methods that simultaneously quantify nicotine, cotinine, trans-3'-hydroxycotinine, nornicotine and norcotinine in human meconium. Such a method could improve identification of in utero tobacco exposure, determine if maternal dose-mecon... |
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Residence times and half-lives of nicotine metabolites in rat brain after acute peripheral administration of [2'-(14)C]nicotine.
Drug Metab. Dispos. 27 , 1448, (1999) The residence times of nicotine and its metabolites in rat brain after acute peripheral nicotine administration were determined. We hypothesize that nicotine metabolites will reach pharmacologically significant concentrations in brain. Cotinine, nornicotine, ... |
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Metabolites of nicotine in rat brain after peripheral nicotine administration. Cotinine, nornicotine, and norcotinine.
Drug Metab. Dispos. 25(1) , 47-54, (1997) The time course of nicotine metabolite appearance in brain from 5 min-18 hr after subcutaneous administration of S-(-)-[3H-N-methyl]nicotine was determined. Results demonstrated that metabolite appearance in brain was greatest at 4 hr postadministration, wher... |
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A validated method for the determination of nicotine, cotinine, trans-3'-hydroxycotinine, and norcotinine in human plasma using solid-phase extraction and liquid chromatography-atmospheric pressure chemical ionization-mass spectrometry.
J. Mass Spectrom. 41(6) , 815-21, (2006) A liquid chromatographic-mass spectrometric method for the simultaneous determination of nicotine, cotinine, trans-3'-hydroxycotinine, and norcotinine in human plasma was developed and validated. Analytes and deuterated internal standards were extracted from ... |
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Simultaneous quantification of nicotine, cotinine, trans-3'-hydroxycotinine, norcotinine and mecamylamine in human urine by liquid chromatography-tandem mass spectrometry.
Clin. Chim. Acta 413(11-12) , 978-84, (2012) Mecamylamine is a nicotine antagonist under investigation in combination with nicotine replacement for smoking treatment.A simple, rapid and reliable liquid chromatography tandem mass spectrometry (LCMSMS) method was developed and validated for quantifying ni... |
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Optimization and validation of a liquid chromatography-tandem mass spectrometry method for the simultaneous quantification of nicotine, cotinine, trans-3'-hydroxycotinine and norcotinine in human oral fluid.
Anal. Bioanal. Chem 395(7) , 2349-57, (2009) An analytical procedure was developed and validated for the simultaneous identification and quantification of nicotine, cotinine, trans-3'-hydroxycotinine, and norcotinine in 0.5 mL of human oral fluid collected with the Quantisal oral fluid collection device... |
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Effect of grapefruit juice on cytochrome P450 2A6 and nicotine renal clearance.
Clin. Pharmacol. Ther. 80(5) , 522-30, (2006) Grapefruit juice is an inhibitor of the cytochrome P450 (CYP) 3A4 enzyme and transporters such as P-glycoprotein and organic anion transporting polypeptides, leading to clinically important interactions. Our objective was to study the effect of grapefruit jui... |
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Simultaneous and sensitive measurement of nicotine, cotinine, trans-3'-hydroxycotinine and norcotinine in human plasma by liquid chromatography-tandem mass spectrometry.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 877(29) , 3537-42, (2009) An LC-MS/MS method for the simultaneous quantification of nicotine, cotinine, trans-3'-hydroxycotinine and norcotinine in human plasma was developed and fully validated. Potential endogenous and exogenous interferences were extensively evaluated and limits of... |