ETIZOLAM
ETIZOLAM structure
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Common Name | ETIZOLAM | ||
|---|---|---|---|---|
| CAS Number | 40054-69-1 | Molecular Weight | 342.846 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 545.3±60.0 °C at 760 mmHg | |
| Molecular Formula | C17H15ClN4S | Melting Point | 147-148ºC | |
| MSDS | N/A | Flash Point | 283.6±32.9 °C | |
| Symbol |
GHS02, GHS06, GHS08 |
Signal Word | Danger | |
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[Chronic subdural hematoma--recurrence and prevention].
Brain Nerve 63(1) , 69-74, (2011) Chronic subdural hematoma is one of the most common disorders observed in routine neurosurgical care. In the vast majority of cases, this disorder is treated by surgical evacuation, which usually yields a good prognosis. However, the recurrence rates after th... |
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Benzodiazepine metabolism: an analytical perspective.
Curr. Drug Metab. 9(8) , 827-44, (2008) Benzodiazepines are currently among the most frequently prescribed drugs all over the world. They act as anxiolytics, sedatives, hypnotics, amnesics, antiepileptics and muscle relaxants. Despite their common chemical scaffold, these drugs differ in their phar... |
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Prevention of overlapping prescriptions of psychotropic drugs by community pharmacists.
Nihon Arukoru. Yakubutsu Igakkai Zasshi 47(5) , 202-10, (2012) The nonmedical use or abuse of prescription drugs, including psychotropic medicines, is a growing health problem in Japan. Patient access to psychotropic drugs, specifically from the oversupply of medications due to overlapping prescriptions, may increase the... |
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Induction of the metabolism of etizolam by carbamazepine in humans.
Eur. J. Clin. Pharmacol. 61(3) , 185-8, (2005) To examine the effect of carbamazepine on the single oral dose pharmacokinetics of etizolam.Eleven healthy male volunteers received carbamazepine 200 mg/day or placebo for 6 days in a double-blind, randomized, crossover manner, and on the sixth day they recei... |
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Rebound insomnia induced by abrupt withdrawal of hypnotics in sleep-disturbed rats.
Eur. J. Pharmacol. 597(1-3) , 46-50, (2008) The present study was performed to examine whether or not rebound insomnia is caused by an abrupt withdrawal of benzodiazepine hypnotics and tandospirone in rats. Etizolam and triazolam caused a significant shortening of sleep latency, increase in non-REM sle... |
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Low tolerance and dependence liabilities of etizolam: molecular, functional, and pharmacological correlates.
Eur. J. Pharmacol. 519(1-2) , 31-42, (2005) The effects of prolonged exposure to and subsequent withdrawal of the thienotriazolobenzodiazepine etizolam on gamma-aminobutyric acid (GABA) type A receptor gene expression and function were compared with those of the benzodiazepine lorazepam. Exposure of ra... |
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Case report: Etizolam and its major metabolites in two unnatural death cases.
Forensic Sci. Int. 182(1-3) , e1-6, (2008) A simultaneous analytical method for etizolam and its main metabolites (alpha-hydroxyetizolam and 8-hydroxyetizolam) in whole blood was developed using solid-phase extraction, TMS derivatization and ion trap gas chromatography tandem mass spectrometry (GC-MS/... |
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Effects of concomitant fluvoxamine on the plasma concentration of etizolam in Japanese psychiatric patients: wide interindividual variation in the drug interaction.
Ther. Drug Monit. 26(6) , 638-42, (2004) Administration of fluvoxamine with concomitant benzodiazepines is common in clinical situations. This study investigated the effects of the coadministration of fluvoxamine on plasma concentrations of etizolam and evaluated the effects of various fluvoxamine d... |
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Effects of different cyclodextrins on the morphology, loading and release properties of poly (DL-lactide-co-glycolide)-microparticles containing the hypnotic agent etizolam.
J. Microencapsul. 24(3) , 214-24, (2007) The aim of this study was to gain insight into the feasibility of using microparticles (MPs) constituted by the biodegradable poly (DL-lactide-co-glycolide) (PLGA) and a number of cyclodextrins (CDs) as an orally sustained delivery system of the hypnotic agen... |
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A case of thalamic pain successfully treated with Kampo medicine.
J. Altern. Complement. Med. 17(6) , 567-70, (2011) Thalamic pain, one of the central painful poststroke symptoms, is a severe pain that is often intractable. A case of thalamic pain successfully treated with Kampo medicine is presented.A 65-year-old woman complained of moderate continuous and paroxysmal sever... |