Sodium [(4-aminobenzoyl)amino]acetate

Sodium [(4-aminobenzoyl)amino]acetate Structure
Sodium [(4-aminobenzoyl)amino]acetate structure
Common Name Sodium [(4-aminobenzoyl)amino]acetate
CAS Number 94-16-6 Molecular Weight 216.169
Density N/A Boiling Point 517.2ºC at 760 mmHg
Molecular Formula C9H9N2NaO3 Melting Point 123-125°C
MSDS Chinese USA Flash Point 266.6ºC

Balanced Hydroxyethylstarch (HES 130/0.4) Impairs Kidney Function In-Vivo without Inflammation.

PLoS ONE 10 , e0137247, (2015)

Volume therapy is a standard procedure in daily perioperative care, and there is an ongoing discussion about the benefits of colloid resuscitation with hydroxyethylstarch (HES). In sepsis HES should be avoided due to a higher risk for acute kidney injury (AKI...

Flavonoid conjugates interact with organic anion transporters (OATs) and attenuate cytotoxicity of adefovir mediated by organic anion transporter 1 (OAT1/SLC22A6).

Biochem. Pharmacol. 81 , 942-949, (2011)

Flavonoids are conjugated by phase II enzymes in humans to form glucuronidated and sulfated metabolites that are excreted in urine via the kidney. In this study, we examined the interaction between metabolites of quercetin and isoflavonoids found in vivo with...

Molecular evidence for an involvement of organic anion transporters (OATs) in aristolochic acid nephropathy.

Toxicology 264 , 74-79, (2009)

Aristolochic acid (AA), present in Aristolochia species, is the major causative agent in the development of severe renal failure and urothelial cancers in patients with AA nephropathy. It may also be a cause of Balkan endemic nephropathy. Epithelial cells of ...

Molecular and functional identification of organic anion transporter isoforms in cultured bovine mammary epithelial cells (BME-UV).

J. Vet. Pharmacol. Ther. 35(3) , 209-15, (2011)

Mammary epithelial cells express a diversity of membrane transporters including members of organic cation and organic anion (OAT) transporter subfamilies. Four mammal OAT isoforms have been identified: OAT-1, OAT-2, OAT-3, and OAT-4. The pharmacological signi...

Pharmacokinetics of p-Aminohippuric Acid and Inulin in Rabbits with Aristolochic Acid Nephropathy.

Adv. Pharmacol. Sci. 2011 , 204501, (2011)

The characteristics of aristolochic acid nephropathy (AAN) are interstitial fibrosis and atrophy of the proximal tubules, but with no change in glomeruli. To investigate the effects of AA on renal functions and the pharmacokinetics (PKs) of p-aminohippuric ac...

Determining the mechanisms underlying augmented renal drug clearance in the critically ill: use of exogenous marker compounds.

Crit. Care 18 , 657, (2015)

The aim of this study was to explore changes in glomerular filtration (GFR) and renal tubular function in critically ill patients at risk of augmented renal clearance (ARC), using exogenous marker compounds.This prospective, observational pharmacokinetic (PK)...