Ouabain Octahydrate
Ouabain Octahydrate structure
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Common Name | Ouabain Octahydrate | ||
|---|---|---|---|---|
| CAS Number | 11018-89-6 | Molecular Weight | 584.653 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 838.2±65.0 °C at 760 mmHg | |
| Molecular Formula | C29H60O20 | Melting Point | 260ºC | |
| MSDS | Chinese USA | Flash Point | 272.9±27.8 °C | |
| Symbol |
GHS06, GHS08 |
Signal Word | Danger | |
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Crystals of Na(+)/K(+)-ATPase with bound cisplatin.
Biochem. Pharmacol. 92(3) , 494-8, (2014) Cisplatin is the most widely used chemotherapeutics for cancer treatment, however, its administration is connected to inevitable adverse effects. Previous studies suggested that cisplatin is able to inhibit Na(+)/K(+)-ATPase (NKA), the enzyme responsible for ... |
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A survey of detergents for the purification of stable, active human cystic fibrosis transmembrane conductance regulator (CFTR).
Biochim. Biophys. Acta 1838(11) , 2825-37, (2014) Structural knowledge of the cystic fibrosis transmembrane conductance regulator (CFTR) requires developing methods to purify and stabilize this aggregation-prone membrane protein above 1mg/ml. Starting with green fluorescent protein- and epitope-tagged human ... |
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Motesanib (AMG706), a potent multikinase inhibitor, antagonizes multidrug resistance by inhibiting the efflux activity of the ABCB1.
Biochem. Pharmacol. 90(4) , 367-78, (2014) Cancer cells often become resistant to chemotherapy through a phenomenon known as multidrug resistance (MDR). Several factors are responsible for the development of MDR, preeminent among them being the accelerated drug efflux mediated by overexpression of ATP... |
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Caspase-dependent cell death-associated release of nucleosome and damage-associated molecular patterns.
Cell Death Dis. 5 , e1494, (2014) Apoptosis, which is anti-inflammatory, and necrosis, which is pro-inflammatory, represent the extremes of the cell death spectrum. Cell death is complex and both apoptosis and necrosis can be observed in the same cells or tissues. Here, we introduce a novel c... |
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Inactivation of Src-to-ezrin pathway: a possible mechanism in the ouabain-mediated inhibition of A549 cell migration.
Biomed Res. Int. 2015 , 537136, (2015) Ouabain, a cardiac glycoside found in plants, is primarily used in the treatment of congestive heart failure and arrhythmia because of its ability to inhibit Na(+)/K(+)-ATPase pump. Recently ouabain has been shown to exert anticancer effects but the underlyin... |
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Digoxin and adenosine triphosphate enhance the functional properties of tissue-engineered cartilage.
Tissue Eng. Part A 21(5-6) , 884-94, (2015) Toward developing engineered cartilage for the treatment of cartilage defects, achieving relevant functional properties before implantation remains a significant challenge. Various chemical and mechanical stimuli have been used to enhance the functional prope... |
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Ouabain induces nitric oxide release by a PI3K/Akt-dependent pathway in isolated aortic rings from rats with heart failure.
J. Cardiovasc. Pharmacol. 65(1) , 28-38, (2015) Ouabain occurs in nanomolar concentrations in myocardial infarction and heart failure (HF). However, the effects of ouabain in vascular function in HF conditions were not investigated yet. Therefore, we analyzed the effects of acute administration of 3 nM oua... |
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Regulatory volume increase in astrocytes exposed to hypertonic medium requires β1 -adrenergic Na(+) /K(+) -ATPase stimulation and glycogenolysis.
J. Neurosci. Res. 93(1) , 130-9, (2014) The cotransporter of Na(+) , K(+) , 2Cl(-) , and water, NKKC1, is activated under two conditions in the brain, exposure to highly elevated extracellular K(+) concentrations, causing astrocytic swelling, and regulatory volume increase in cells shrunk in respon... |
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Molecular cloning and functional characterization of a rainbow trout liver Oatp.
Toxicol. Appl. Pharmacol. 280(3) , 534-42, (2014) Cyanobacterial blooms have an impact on the aquatic ecosystem due to the production of toxins (e.g. microcystins, MCs), which constrain fish health or even cause fish death. However the toxicokinetics of the most abundant toxin, microcystin-LR (MC-LR), are no... |
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The putative role of the non-gastric H⁺/K⁺-ATPase ATP12A (ATP1AL1) as anti-apoptotic ion transporter: effect of the H⁺/K⁺ ATPase inhibitor SCH28080 on butyrate-stimulated myelomonocytic HL-60 cells.
Cell Physiol. Biochem. 34(5) , 1507-26, (2014) The ATP12A gene codes for a non-gastric H(+)/K(+) ATPase, which is expressed in a wide variety of tissues. The aim of this study was to test for the molecular and functional expression of the non-gastric H(+)/K(+) ATPase ATP12A/ATP1AL1 in unstimulated and but... |