Dihydrocodeine
Dihydrocodeine structure
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Common Name | Dihydrocodeine | ||
|---|---|---|---|---|
| CAS Number | 125-28-0 | Molecular Weight | 301.380 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 462.0±45.0 °C at 760 mmHg | |
| Molecular Formula | C20H24F3NO4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 233.2±28.7 °C | |
| Symbol |
GHS02, GHS06, GHS08 |
Signal Word | Danger | |
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The advantages and limitations of the analgesics available for control of postoperative pain after a dental procedure.
SAAD Dig. 29 , 70-81, (2013)
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Urine testing for norcodeine, norhydrocodone, and noroxycodone facilitates interpretation and reduces false negatives.
Forensic Sci. Int. 198(1-3) , 58-61, (2010) Urine drug testing of pain patients provides objective information to health specialists regarding patient compliance, diversion, and concurrent illicit drug use. Interpretation of urine test results for semi-synthetic opiates can be difficult because of comp... |
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Quantitation of opioids in whole blood by electron impact-gas chromatography-mass spectrometry.
J. Anal. Toxicol. 35(2) , 99-107, (2011) Opioids are frequently encountered in Forensic Toxicology casework. A PubMed literature search was conducted to find a method using electron impact-gas chromatography-mass spectrometry to examine whole blood specimens. A previously published method was identi... |
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Applications of minimal physiologically-based pharmacokinetic models.
J. Pharmacokinet. Pharmacodyn. 39(6) , 711-23, (2012) Conventional mammillary models are frequently used for pharmacokinetic (PK) analysis when only blood or plasma data are available. Such models depend on the quality of the drug disposition data and have vague biological features. An alternative minimal-physio... |
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Inhibitory effects of opioids on compound action potentials in frog sciatic nerves and their chemical structures
Life Sci. 83(5-6) , 198-207, (2008) An opioid tramadol more effectively inhibits compound action potentials (CAPs) than its metabolite mono- O-demethyl-tramadol (M1). To address further this issue, we examined the effects of opioids (morphine, codeine, ethylmorphine and dihydrocodeine) and coca... |
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Analgesia and serum assays of controlled-release dihydrocodeine and metabolites in cancer patients with pain
Pharmacol. Rep. 64(1) , 84-93, (2012) Abstract Aim of the study was to assess dihydrocodeine (DHC) and metabolites concentrations and their correlations with DHC analgesia in cancer patients with pain. Thirty opioid-naive patients with nociceptive pain intensity assessed by VAS (visual analogue s... |
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The Leeds Evaluation of Efficacy of Detoxification Study (LEEDS) prisons project: a randomised controlled trial comparing dihydrocodeine and buprenorphine for opiate detoxification.
Subst. Abuse Treat. Prev. Policy 4 , 1, (2009) Many opiate users entering British prisons require prescribed medication to help them achieve abstinence. This commonly takes the form of a detoxification regime. Previously, a range of detoxification agents have been prescribed without a clear evidence base ... |
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Analgesic effects and assays of controlled-release tramadol and o-desmethyltramadol in cancer patients with pain.
Curr. Pharm. Biotechnol. 12(2) , 306-12, (2011) To assess tramadol and O-desmethyltramadol (M1) concentrations and their correlations with analgesia in patients with cancer pain.Thirty opioid-naive patients with nociceptive pain intensity on VAS (visual analogue scale) > 40 received controlled-release tram... |
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The role of dihydrocodeine (DHC) metabolites in dihydrocodeine-related deaths.
J. Anal. Toxicol. 34(8) , 476-90, (2010) The focus of this study was to report the blood and urine concentrations of dihydrocodeine (DHC) and its metabolites, dihydrocodeine-6-glucuronide (DHC6G), dihydromorphine (DHM), dihydromorphine-3-glucuronide (DHM3G), and dihydromorphine-6-glucuronide (DHM6G)... |
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Prevalence of dihydrocodeine in hydrocodone positive postmortem specimens
J. Forensic Leg. Med. 16(2) , 64-6, (2009) Hydrocodone (HC) has received renewed interest in the US due to reported increases in opiate related deaths involving psychotherapeutic drugs. The relative contribution of dihydrocodeine (DHC) in these deaths is unknown since little testing of this compound i... |