Rp-8-Br-PET-cGMPs
Rp-8-Br-PET-cGMPs structure
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Common Name | Rp-8-Br-PET-cGMPs | ||
|---|---|---|---|---|
| CAS Number | 185246-32-6 | Molecular Weight | 580.28100 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C18H16BrN5NaO7PS | Melting Point | 240-300ºC(lit.) | |
| MSDS | USA | Flash Point | N/A | |
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B-type natriuretic peptide inhibits angiotensin II-induced proliferation and migration of pulmonary arterial smooth muscle cells.
Pediatr. Pulmonol. 49(8) , 734-44, (2014) Pulmonary vascular remodeling, characterized by disordered proliferation and migration of pulmonary arterial smooth muscle cells (PASMCs), is a pathognomonic feature of pulmonary arterial hypertension. Thus, pharmacologic strategy targeting on anti-proliferat... |
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GLAST/EAAT1 regulation in cultured Bergmann glia cells: role of the NO/cGMP signaling pathway.
Neurochem. Int. 73 , 139-45, (2014) Glutamate, the major excitatory amino acid, activates a wide variety of signal transduction cascades. Ionotropic and metabotropic glutamate receptors are critically involved in long-term synaptic changes, although recent findings suggest that the electrogenic... |
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The NO-cGMP-PKG signaling pathway coordinately regulates ERK and ERK-driven gene expression at pre- and postsynaptic sites following LTP-inducing stimulation of thalamo-amygdala synapses.
Neural Plast. 2010 , 540940, (2011) Long-term potentiation (LTP) at thalamic input synapses to the lateral nucleus of the amygdala (LA) has been proposed as a cellular mechanism of the formation of auditory fear memories. We have previously shown that signaling via ERK/MAPK in both the LA and t... |
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Synaptic plasticity and NO-cGMP-PKG signaling regulate pre- and postsynaptic alterations at rat lateral amygdala synapses following fear conditioning.
PLoS ONE 5 , e11236, (2010) In vertebrate models of synaptic plasticity, signaling via the putative "retrograde messenger" nitric oxide (NO) has been hypothesized to serve as a critical link between functional and structural alterations at pre- and postsynaptic sites. In the present stu... |
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A role for nitric oxide-driven retrograde signaling in the consolidation of a fear memory.
Front. Behav. Neurosci. 4 , 2, (2010) In both invertebrate and vertebrate models of synaptic plasticity, signaling via the putative "retrograde messenger" nitric oxide (NO) has been hypothesized to serve as a critical link between functional and structural alterations at pre- and postsynaptic sit... |
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cNMP-AMs mimic and dissect bacterial nucleotidyl cyclase toxin effects.
Biochem. Biophys. Res. Commun. 451(4) , 497-502, (2014) In addition to the well-known second messengers cAMP and cGMP, mammalian cells contain the cyclic pyrimidine nucleotides cCMP and cUMP. The Pseudomonas aeruginosa toxin ExoY massively increases cGMP and cUMP in cells, whereas the Bordetella pertussis toxin Cy... |
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Effects and mechanisms of action of sildenafil citrate in human chorionic arteries.
Reprod. Biol. Endocrinol. 7 , 34, (2009) Sildenafil citrate, a specific phosphodiesterase-5 inhibitor, is increasingly used for pulmonary hypertension in pregnancy. Sildenafil is also emerging as a potential candidate for the treatment of intra-uterine growth retardation and for premature labor. Its... |
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miR-21/DDAH1 pathway regulates pulmonary vascular responses to hypoxia.
Biochem. J. 462(1) , 103-12, (2014) The NOS (nitric oxide synthase) inhibitor ADMA (asymmetric dimethylarginine) contributes to the pathogenesis of pulmonary hypertension. Reduced levels of the enzymes metabolizing ADMA, dimethylarginine dimethylaminohydrolases (DDAH1 and DDAH2) and increased l... |
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Prolonged exposure of chromaffin cells to nitric oxide down-regulates the activity of soluble guanylyl cyclase and corresponding mRNA and protein levels.
BMC Biochem. 3 , 26, (2002) Soluble guanylyl cyclase (sGC) is the main receptor for nitric oxide (NO) when the latter is produced at low concentrations. This enzyme exists mainly as a heterodimer consisting of one alpha and one beta subunit and converts GTP to the second intracellular m... |
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Endocannabinoids mediate muscarine-induced synaptic depression at the vertebrate neuromuscular junction.
Eur. J. Neurosci. 25 , 1619-30, (2007) Endocannabinoids (eCBs) inhibit neurotransmitter release throughout the central nervous system. Using the Ceratomandibularis muscle from the lizard Anolis carolinensis we asked whether eCBs play a similar role at the vertebrate neuromuscular junction. We repo... |