Rp-8-Br-PET-cGMPs
Modify Date: 2023-01-24 09:46:53
Rp-8-Br-PET-cGMPs structure
|
Common Name | Rp-8-Br-PET-cGMPs | ||
|---|---|---|---|---|
| CAS Number | 185246-32-6 | Molecular Weight | 580.28100 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C18H16BrN5NaO7PS | Melting Point | 240-300ºC(lit.) | |
| MSDS | USA | Flash Point | N/A | |
Use of Rp-8-Br-PET-cGMPsRp-8-bromo-PET-Cyclic GMPS sodium salt is a cell permeable, competitive, and reversible inhibitor of cGMP-dependent protein kinases (cGKs) that blocks activation of cGKI and cGKII by cGMP. |
| Name | sodium,3-[(4aR,6R,7R,7aS)-7-hydroxy-2-oxido-2-sulfanylidene-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]-2-bromo-6-phenyl-5H-imidazo[1,2-a]purin-9-one,hydrate |
|---|
| Melting Point | 240-300ºC(lit.) |
|---|---|
| Molecular Formula | C18H16BrN5NaO7PS |
| Molecular Weight | 580.28100 |
| Exact Mass | 578.95900 |
| PSA | 190.09000 |
| LogP | 2.71680 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Safety Phrases | 22-24/25 |
| RIDADR | NONH for all modes of transport |
|
B-type natriuretic peptide inhibits angiotensin II-induced proliferation and migration of pulmonary arterial smooth muscle cells.
Pediatr. Pulmonol. 49(8) , 734-44, (2014) Pulmonary vascular remodeling, characterized by disordered proliferation and migration of pulmonary arterial smooth muscle cells (PASMCs), is a pathognomonic feature of pulmonary arterial hypertension... |
|
|
GLAST/EAAT1 regulation in cultured Bergmann glia cells: role of the NO/cGMP signaling pathway.
Neurochem. Int. 73 , 139-45, (2014) Glutamate, the major excitatory amino acid, activates a wide variety of signal transduction cascades. Ionotropic and metabotropic glutamate receptors are critically involved in long-term synaptic chan... |
|
|
The NO-cGMP-PKG signaling pathway coordinately regulates ERK and ERK-driven gene expression at pre- and postsynaptic sites following LTP-inducing stimulation of thalamo-amygdala synapses.
Neural Plast. 2010 , 540940, (2011) Long-term potentiation (LTP) at thalamic input synapses to the lateral nucleus of the amygdala (LA) has been proposed as a cellular mechanism of the formation of auditory fear memories. We have previo... |