4-(4-Chlorophenyl)-4-piperidinol
4-(4-Chlorophenyl)-4-piperidinol structure
|
Common Name | 4-(4-Chlorophenyl)-4-piperidinol | ||
|---|---|---|---|---|
| CAS Number | 39512-49-7 | Molecular Weight | 211.688 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 344.5±42.0 °C at 760 mmHg | |
| Molecular Formula | C11H14ClNO | Melting Point | 137-140 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 162.1±27.9 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
|
Antagonism by haloperidol and its metabolites of mechanical hypersensitivity induced by intraplantar capsaicin in mice: role of sigma-1 receptors.
Psychopharmacology 205 , 21-33, (2009) We evaluated the effects of haloperidol and its metabolites on capsaicin-induced mechanical hypersensitivity (allodynia) and on nociceptive pain induced by punctate mechanical stimuli in mice.Subcutaneous administration of haloperidol or its metabolites I or ... |
|
|
In-vitro characterization of the cytochrome P450 isoenzymes involved in the back oxidation and N-dealkylation of reduced haloperidol.
Pharmacogenetics 8(5) , 383-9, (1998) In-vitro studies were performed using human liver microsomes and c-DNA-expressed human P450 isoforms to identify the cytochrome P450 isoenzyme(s) involved in the back oxidation and N-dealkylation of reduced haloperidol. Back oxidation and N-dealkylation of re... |
|
|
Comparison of SSI with APCI as an interface of HPLC-mass spectrometry for analysis of a drug and its metabolites.
J. Am. Soc. Mass Spectrom. 13(3) , 204-8, (2002) Sonic spray ionization (SSI) was compared with atmospheric pressure chemical ionization (APCI) as an interface of high-performance liquid chromatography (HPLC)-mass spectrometry (MS) for sensitive analyses of a neuroleptic drug, haloperidol and its two metabo... |
|
|
Determination of 4-(4-chlorophenyl)-4-hydroxypiperidine, a metabolite of haloperidol, by gas chromatography with electron-capture detection.
J. Chromatogr. B, Biomed. Appl. 682(2) , 283-8, (1996) An electron-capture gas chromatographic procedure was developed for the analysis of 4-(4-chlorophenyl)-4-hydroxypiperidine (CPHP), a metabolite of haloperidol. The assay involved basic extraction of this metabolite from the biological samples, followed by bac... |
|
|
Salt formation in solid dispersions consisting of polyacrylic acid as a carrier and three basic model compounds resulting in very high glass transition temperatures and constant dissolution properties upon storage.
Eur. J. Pharm. Sci. 25(4-5) , 387-93, (2005) The purpose of the study was to investigate the suitability of polyacrylic acid (PAA) as a carrier in solid dispersions, with the aim to delay crystallization of basic drugs and improve their dissolution behaviour. The physicochemical properties were investig... |
|
|
[Chemical toxicological analysis of haloperidol metabolite 4-(4-chlorophenyl)-4-hydroxypipiridine in urine by high-performance liquid chromatography].
Sud. Med. Ekspert. 52(1) , 45-8, (2009) Haloperidol is extensively used in current psychiatric practice for the treatment of various psychotic disorders. However, this substance is known to be toxic and sometimes cause poisoning despite its generally positive therapeutic effect. Moreover, some of i... |
|
|
Sensitive determination of 4-(4-chlorophenyl)-4-hydroxypiperidine, a metabolite of haloperidol, in a rat biological sample by HPLC with fluorescence detection after pre-column derivatization using 4-fluoro-7-nitro-2,1,3-benzoxadiazole.
Biomed. Chromatogr. 20(9) , 964-70, (2006) 4-(4-Chlorophenyl)-4-hydroxypiperidine (CPHP), one of the metabolites of haloperidol, is considered to exhibit brain toxicity. CPHP concentrations in plasma and tissue homogenates (each 200 microL) from rats were analyzed by HPLC fluorescence detection after ... |