Chromanol 293B
Chromanol 293B structure
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Common Name | Chromanol 293B | ||
|---|---|---|---|---|
| CAS Number | 163163-23-3 | Molecular Weight | 324.39500 | |
| Density | 1.33g/cm3 | Boiling Point | 474.1ºC at 760mmHg | |
| Molecular Formula | C15H20N2O4S | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Genetic Inhibition Of The Ubiquitin Ligase Rnf5 Attenuates Phenotypes Associated To F508del Cystic Fibrosis Mutation.
Sci. Rep. 5 , 12138, (2015) Cystic fibrosis (CF) is caused by mutations in the CFTR chloride channel. Deletion of phenylalanine 508 (F508del), the most frequent CF mutation, impairs CFTR trafficking and gating. F508del-CFTR mistrafficking may be corrected by acting directly on mutant CF... |
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Drosophila KCNQ channel displays evolutionarily conserved electrophysiology and pharmacology with mammalian KCNQ channels.
PLoS ONE 6(9) , e23898, (2011) Of the five human KCNQ (Kv7) channels, KCNQ1 with auxiliary subunit KCNE1 mediates the native cardiac I(Ks) current with mutations causing short and long QT cardiac arrhythmias. KCNQ4 mutations cause deafness. KCNQ2/3 channels form the native M-current contro... |
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Effects of KCNQ channel modulators on the M-type potassium current in primate retinal pigment epithelium.
Am. J. Physiol. Cell Physiol. 302(5) , C821-33, (2012) Recently, we demonstrated the expression of KCNQ1, KCNQ4, and KCNQ5 transcripts in monkey retinal pigment epithelium (RPE) and showed that the M-type current in RPE cells is blocked by the specific KCNQ channel blocker XE991. Using patch-clamp electrophysiolo... |
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A Simple Protocol for the Myocardial Differentiation of Human iPS Cells.
Biol. Pharm. Bull. 38 , 1070-5, (2015) We have developed a simple protocol for inducing the myocardial differentiation of human induced pluripotent stem (iPS) cells. Human iPS cell-derived embryonic bodies (EBs) were treated with a combination of activin-A, bone morphogenetic protein-4 and wnt-3a ... |
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Nobiletin Stimulates Chloride Secretion in Human Bronchial Epithelia via a cAMP/PKA-Dependent Pathway.
Cell Physiol. Biochem. 37 , 306-20, (2015) Nobiletin, a citrus flavonoid isolated from tangerines, alters ion transport functions in intestinal epithelia, and has antagonistic effects on eosinophilic airway inflammation of asthmatic rats. The present study examined the effects of nobiletin on basal sh... |
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Molecular and functional characterization of Kv7 K+ channel in murine gastrointestinal smooth muscles.
Am. J. Physiol. Gastrointest. Liver Physiol. 297(1) , G107-15, (2009) Members of the K(v)7 voltage-gated K(+) channel family are important determinants of cardiac and neuronal membrane excitability. Recently, we and others have shown that K(v)7 channels are also crucial regulators of smooth muscle activity. The aim of the prese... |
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Mechanisms of secretion-associated shrinkage and volume recovery in cultured rabbit parietal cells.
Am. J. Physiol. Gastrointest. Liver Physiol. 292(3) , G711-7, (2007) We have previously shown that stimulation of acid secretion in parietal cells causes rapid initial cell shrinkage, followed by Na(+)/H(+) exchange-mediated regulatory volume increase (RVI). The factors leading to the initial cell shrinkage are unknown. We the... |
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Real time measurements of water flow in amphibian gastric glands: modulation via the extracellular Ca2+-sensing receptor.
J. Biol. Chem. 282(18) , 13477-86, (2007) The mechanisms for the formation of the osmotic gradient driving water movements in the gastric gland and its modulation via the extracellular Ca(2+)-sensing receptor (CaR) were investigated. Real time measurements of net water flux in the lumen of single gas... |
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Models of torsades de pointes: effects of FPL64176, DPI201106, dofetilide, and chromanol 293B in isolated rabbit and guinea pig hearts.
J. Pharmacol. Toxicol. Methods 60(2) , 174-84, (2009) For studying the torsades de pointes (TdP) liability of a compound, most high and medium throughput methods use surrogate markers such as HERG inhibition and QT prolongation. In this study, we have tested whether isolated hearts may be modified to allow TdP t... |
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Effects of potassium channel blockers on changes in refractoriness of atrial cardiomyocytes induced by stretch.
Exp. Biol. Med. (Maywood.) 234(7) , 779-84, (2009) Shortening of the effective refractory period (ERP) is regarded as one of the key mechanisms of atrial fibrillation (AF). Stretch is an important predisposing factor in the pathogenesis of AF. However, effective methods to counteract alteration of ERP induced... |