flurazepam
flurazepam structure
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Common Name | flurazepam | ||
|---|---|---|---|---|
| CAS Number | 17617-23-1 | Molecular Weight | 387.87800 | |
| Density | 1.21g/cm3 | Boiling Point | 551.4ºC at 760mmHg | |
| Molecular Formula | C21H23ClFN3O | Melting Point | 77-82° | |
| MSDS | N/A | Flash Point | 287.2ºC | |
| Symbol |
GHS02, GHS06, GHS08 |
Signal Word | Danger | |
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Folie à deux: a case report.
Clin. Schizophr. Relat. Psychoses 7(2) , 93-6, (2013) Folie à deux is a relatively rare mental disorder first described in France in 1877 by Lasègue and Falret. However, folie à deux is still a matter of study and debate today as it remains a challenge for psychiatrists. The aim of our work is to report a clinic... |
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LC-MS/MS analysis of 13 benzodiazepines and metabolites in urine, serum, plasma, and meconium.
Methods Mol. Biol. 603 , 89-105, (2010) We describe a single method for the detection and quantitation of 13 commonly prescribed benzodiazepines and metabolites: alpha-hydroxyalprazolam, alpha-hydroxyethylflurazepam, alpha-hydroxytriazolam, alprazolam, desalkylflurazepam, diazepam, lorazepam, midaz... |
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Gender differences in highway driving performance after administration of sleep medication: a review of the literature.
Traffic Inj. Prev. 13(3) , 286-92, (2012) It is generally assumed that there are minimal gender differences in the safety and efficacy of central nervous system drugs, as is evidenced by men and women receiving the same drug dosage. There is, however, evidence that drugs may have a differential effec... |
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Ignition of a human body by a modest external source: a case report.
Forensic Sci. Int. 188(1-3) , e17-9, (2009) A case of sustained combustion of a human body that occurred in 2006 in Geneva, Switzerland, is presented. The body of a man was discovered at home and found to have been almost completely incinerated between the knees and the mid-chest, with less damage to t... |
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Flurazepam inhibits the P-glycoprotein transport function: an insight to revert multidrug-resistance phenotype.
Eur. J. Pharmacol. 581(1-2) , 30-6, (2008) P-glycoprotein mediated drug transport may lead to a multidrug resistance phenotype often associated with a poor response to the successful treatment of a variety of human disorders. Several agents have been found to modulate P-glycoprotein drug resistance, m... |
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Testing the silence of mutations: Transcriptomic and behavioral studies of GABA(A) receptor α1 and α2 subunit knock-in mice.
Neurosci. Lett. 488(1) , 31-5, (2011) Knock-in mice were constructed with mutations in the α1 (H(270), A(277)) and α2 (H(270), A(277)) subunits of the GABAA receptor, which resulted in receptors that lacked modulation by ethanol but retained normal responses to GABA in vitro. A key question is wh... |
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17beta-estradiol affects GABAergic transmission in developing hippocampus.
Brain Res. 1241 , 7-17, (2008) Estrogens are potent modulators of the nervous system. In particular, 17beta-estradiol was shown to affect GABAergic synaptic transmission in hippocampus of adult animals in vivo but much less is known on the impact of this hormone on the GABAergic system in ... |
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Chronic benzodiazepine-induced reduction in GABA(A) receptor-mediated synaptic currents in hippocampal CA1 pyramidal neurons prevented by prior nimodipine injection.
Neuroscience 157(1) , 153-63, (2008) One week oral flurazepam (FZP) administration in rats results in reduced GABA(A) receptor-mediated synaptic transmission in CA1 pyramidal neurons associated with benzodiazepine tolerance in vivo and in vitro. Since voltage-gated calcium channel (VGCC) current... |
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Genetically inbred Balb/C mice are more sensitive to an effect of flurazepam and more resistant to an effect of stress than a genetically outbred mouse strain
Epilepsy Behav. 16(3) , 415-7, (2009) The inbred Balb/c mouse strain was more sensitive than the outbred NIH Swiss mouse to flurazepam’s ability to antagonize electrically precipitated seizures. In prior work, a reduction in flurazepam’s antiseizure efficacy was not observed 24 h after forcing Ba... |
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Regulation of Ca²⁺/calmodulin-dependent protein kinase II signaling within hippocampal glutamatergic postsynapses during flurazepam withdrawal.
Neural Plast. 2012 , 405926, (2012) Cessation of one-week oral administration of the benzodiazepine flurazepam (FZP) to rats results in withdrawal anxiety after 1 day of withdrawal. FZP withdrawal is correlated with synaptic incorporation of homomeric GluA1-containing α-amino-3-hydroxy-5-methyl... |