4-(methylsulfonyl)phenylboronic acid
4-(methylsulfonyl)phenylboronic acid structure
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Common Name | 4-(methylsulfonyl)phenylboronic acid | ||
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| CAS Number | 149104-88-1 | Molecular Weight | 200.02 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 445.5±51.0 °C at 760 mmHg | |
| Molecular Formula | C7H9BO4S | Melting Point | 275-277 °C | |
| MSDS | Chinese USA | Flash Point | 223.2±30.4 °C | |
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3,5-Diaryl-2-aminopyridines as a novel class of orally active antimalarials demonstrating single dose cure in mice and clinical candidate potential.
J. Med. Chem. 7th ed., 55 , 3479-3487, (2012) A novel class of orally active antimalarial 3,5-diaryl-2-aminopyridines has been identified from phenotypic whole cell high-throughput screening of a commercially available SoftFocus kinase library. The compounds were evaluated in vitro for their antiplasmodi... |
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Copper-catalyzed oxidative trifluoromethylthiolation of aryl boronic acids with TMSCF3 and elemental sulfur.
Angew. Chem. Int. Ed. Engl. 10th ed., 51 , 2492-2495, (2012)
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Synthesis of unsymmetrical 3,4-diaryl-3-pyrrolin-2-ones utilizing pyrrole Weinreb amides.
J. Org. Chem. 76 , 8203-8214, (2011) A regiocontrolled synthesis of unsymmetrical 3,4-diaryl-3-pyrrolin-2-ones has been achieved in three steps from 1,2-diaryl-1-nitroethenes with pyrrole-2-carboxamides (pyrrole Weinreb amides) serving as the key linchpin intermediates. Two different methods for... |
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Synthesis and biological evaluation of new 3-(6-hydroxyindol-2-yl)-5-(Phenyl) pyridine or pyrazine V-Shaped molecules as kinase inhibitors and cytotoxic agents.
Eur. J. Med. Chem. 11th ed., 46 , 5416-5434, (2011) We here report the synthesis and biological evaluation of new 3-[(2-indolyl)]-5-phenyl-3,5-pyridine, 3-[(2-indolyl)]-5-phenyl-2,4-pyridine and 3-[(2-indolyl)]-5-phenyl-2,6-pyrazine derivatives designed as potential CDK inhibitors. Indoles and phenyls were use... |
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Highly selective rhodium-catalyzed conjugate addition reactions of 4-oxobutenamides.
J. Org. Chem. 72 , 8870, (2007) A variety of 4-oxobutenamides 1 were subjected to rhodium-catalyzed conjugate addition with arylboronic acids providing high regio- and enantioselectivity (97:3 to >99:1, >96% ee) and moderate to excellent yields (54-99%). The key to high selectivity is the u... |
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The design, synthesis and biological evaluations of C-6 or C-7 substituted 2-hydroxyisoquinoline-1,3-diones as inhibitors of hepatitis C virus.
Bioorg. Med. Chem. 1st ed., 20 , 467-479, (2012) C7-Substituted 2-hydroxyisoquinoline-1,3-diones inhibit the strand transfer of HIV integrase (IN) and the reverse-transcriptase-associated ribonuclease H (RNH). Hepatitis C virus (HCV) NS5B polymerase shares a similar active site fold to RNH and IN, suggestin... |
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Directed metalation and regioselective functionalization of 3-bromofuran and related heterocycles with NaHMDS
Tetrahedron Lett. 2nd ed., 53 , 166-169, (2012)
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Facile Access to 3,5-Dihalogenated Pyrazoles by Sydnone Cycloaddition and their Versatile Functionalization by Pd-Catalyzed Cross-Coupling Processes Delaunay, T.; et al.
Eur. J. Med. Chem. 20-21 , 3837-3848, (2011)
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Synthesis of 2,6-disubstituted-7,8-dihydro-6H-pyrano[2,3-b]pyrazines Li, J-C.; et al.
Tetrahedron Lett. 7th ed., 53 , 852-853, (2012)
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Identification of biaryl sulfone derivatives as antagonists of the histamine H3 receptor: Discovery of (R)-1-(2-(4'-(3-methoxypropylsulfonyl)biphenyl-4-yl)ethyl)-2-methylpyrrolidine (APD916) Semple, G.; et al.
Bioorg. Med. Chem. 1st ed., 21 , 71-75, (2012)
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