phencyclidine
phencyclidine structure
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Common Name | phencyclidine | ||
|---|---|---|---|---|
| CAS Number | 77-10-1 | Molecular Weight | 243.38700 | |
| Density | 1.013 g/cm3 | Boiling Point | 340ºC at 760 mmHg | |
| Molecular Formula | C17H25N | Melting Point | 46.5℃ | |
| MSDS | N/A | Flash Point | 11ºC | |
| Symbol |
GHS02, GHS06, GHS08 |
Signal Word | Danger | |
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Ontogenetic influence on rat susceptibility to lindane seizure after pretreatment with phencyclidine.
Environ. Toxicol. Pharmacol. 35(2) , 161-70, (2013) The aim of the study was to determine the effects of early postnatal PCP treatment on the sensitivity of pubertal and adult rats to lindane proepileptogenic effects. Rat pups were treated with NaCl (0.9%) or PCP (10 mg/kg) at postnatal days 2, 6, 9 and 12. On... |
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Behavioral phenotypes in schizophrenic animal models with multiple combinations of genetic and environmental factors.
J. Pharmacol. Sci. 121(3) , 185-91, (2013) Schizophrenia is a multifactorial psychiatric disorder in which both genetic and environmental factors play a role. Genetic [e.g., Disrupted-in-schizophrenia 1 (DISC1), Neuregulin-1 (NRG1)] and environmental factors (e.g., maternal viral infection, obstetric ... |
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Cariprazine, a dopamine D(3)-receptor-preferring partial agonist, blocks phencyclidine-induced impairments of working memory, attention set-shifting, and recognition memory in the mouse.
Psychopharmacology 226(1) , 91-100, (2013) A major challenge in the pharmacological treatment of psychotic disorders is the effective management of the associated cognitive dysfunctions. Novel concepts emphasize a potential benefit of partial agonists acting upon dopamine D(2)-like receptors in amelio... |
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mGluR5 antagonist-induced psychoactive properties: MTEP drug discrimination, a pharmacologically selective non-NMDA effect with apparent lack of reinforcing properties.
J. Pharmacol. Exp. Ther. 349(1) , 155-64, (2014) Fenobam [N-(3-chlorophenyl)-N'-(4,5-dihydro-1-methyl-4-oxo-1H-imidazole-2-yl)urea], a potent metabotropic glutamate mGluR5 receptor antagonist, reported to have analgesic effects in animals and anxiolytic effects in humans, also caused adverse events, includi... |
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Differential effects of subchronic phencyclidine on anxiety in the light-enhanced startle-, light/dark exploration- and open field tests.
Behav. Brain Res. 243 , 61-5, (2013) Subchronic treatment with the N-methyl-d-aspartate receptor antagonist phencyclidine (PCP) is a valuable approach to model the symptomatology of schizophrenia, a multi-facetted psychiatric disorder, in rodents. We addressed the question whether subchronic PCP... |
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How often do false-positive phencyclidine urine screens occur with use of common medications?
Clin. Toxicol. (Phila.) 51(6) , 493-6, (2013) Previous reports describe false-positive urine immunoassay screens for phencyclidine (PCP) associated with use of tramadol, dextromethorphan, or diphenhydramine. The likelihood of these false positives is unknown.We sought to find the relative frequency of fa... |
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Chronic cannabinoid exposure reduces phencyclidine-induced schizophrenia-like positive symptoms in adult rats.
Psychopharmacology 225(3) , 531-42, (2013) Chronic cannabis use can induce psychotic states that resemble schizophrenia. Yet, schizophrenic patients often smoke cannabis as a form of self-medication to counter the aversive symptoms of schizophrenia. We recently demonstrated an ameliorating effect of c... |
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Reduction in phencyclidine induced sensorimotor gating deficits in the rat following increased system xc⁻ activity in the medial prefrontal cortex.
Psychopharmacology 226(3) , 531-40, (2013) Aspects of schizophrenia, including deficits in sensorimotor gating, have been linked to glutamate dysfunction and/or oxidative stress in the prefrontal cortex. System xc(-), a cystine-glutamate antiporter, is a poorly understood mechanism that contributes to... |
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Neonatal administration of phencyclidine decreases the number of putative inhibitory interneurons and increases neural excitability to auditory paired clicks in the hippocampal CA3 region of freely moving adult mice.
Neuroscience 224 , 268-81, (2012) Animals exposed to phencyclidine (PCP) during the neonatal period have fewer GABAergic interneurons in the corticolimbic area, including the hippocampus, and exhibit abnormal behaviors after attaining maturation that correspond with schizophrenic symptoms. Si... |
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Use of haloperidol in PCP-intoxicated individuals.
Clin. Toxicol. (Phila.) 50(9) , 851-3, (2012) Emergency medical workers often experience violence while performing their job functions. Phencyclidine (PCP)-intoxicated patients are often violent and difficult to control physically. A chemical restraint is frequently needed to assist in protecting both pa... |