Thymoquinone
Thymoquinone structure
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Common Name | Thymoquinone | ||
|---|---|---|---|---|
| CAS Number | 490-91-5 | Molecular Weight | 164.201 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 232.0±15.0 °C at 760 mmHg | |
| Molecular Formula | C10H12O2 | Melting Point | 167 ºC | |
| MSDS | Chinese USA | Flash Point | 103.9±0.0 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Thymoquinone Pretreatment Overcomes the Insensitivity and Potentiates the Antitumor Effect of Gemcitabine Through Abrogation of Notch1, PI3K/Akt/mTOR Regulated Signaling Pathways in Pancreatic Cancer.
Dig. Dis. Sci. 60 , 1067-80, (2015) The gemcitabine-insensitivity remains the main challenge for pancreatic cancer treatment. Thymoquinone, the predominant bioactive ingredient of Nigella sativa, has been shown to possess promising anti-cancer and chemo-sensitizing effects on pancreatic cancer,... |
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Thymoquinone restores radiation-induced TGF-β expression and abrogates EMT in chemoradiotherapy of breast cancer cells.
J. Cell Physiol. 230(3) , 620-9, (2015) Radiotherapy remains a prime approach to adjuvant therapies in patients with early and advanced breast cancer. In spite of therapeutic success, metastatic progression in patients undergoing therapy, limits its application. However, effective therapeutic strat... |
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Evaluation of Antioxidant and Antibacterial Potentials of Nigella sativa L. Suspension Cultures under Elicitation.
Biomed Res. Int. 2015 , 708691, (2015) Nigella sativa L. (family Ranunculaceae) is an annual herb of immense medicinal properties because of its major active components (i.e., thymoquinone (TQ), thymohydroquinone (THQ), and thymol (THY)). Plant tissue culture techniques like elicitation, Agrobacte... |
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Identification of odorants in frankincense (Boswellia sacra Flueck.) by aroma extract dilution analysis and two-dimensional gas chromatography-mass spectrometry/olfactometry.
Phytochemistry 109 , 66-75, (2014) Frankincense has been known, traded and used throughout the ages for its exceptional aroma properties, and is still commonly used in both secular and religious settings to convey a pleasant odor. Surprisingly, the odoriferous principle(s) underlying its uniqu... |
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In vitro and in vivo anti-plasmodial activity of essential oils, including hinokitiol.
Southeast Asian J. Trop. Med. Public Health 43(2) , 270-9, (2012) Abstract. The anti-plasmodial activity of 47 essential oils and 10 of their constituents were screened for in vitro activity against Plasmodium falciparum. Five of these essential oils (sandalwood, caraway, monarda, nutmeg, and Thujopsis dolabrata var. hondai... |
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Thymoquinone inhibits murine leukemia WEHI-3 cells in vivo and in vitro.
PLoS ONE 9(12) , e115340, (2014) Thymoquinone is an active ingredient isolated from Nigella sativa (Black Seed). This study aimed to evaluate the in vitro and in vivo anti-leukemic effects of thymoquinone on WEHI-3 cells.The cytotoxic effect of thymoquinone was assessed using an MTT assay, w... |
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Distribution of primary and specialized metabolites in Nigella sativa seeds, a spice with vast traditional and historical uses.
Molecules 17(9) , 10159-77, (2012) Black cumin (Nigella sativa L., Ranunculaceae) is an annual herb commonly used in the Middle East, India and nowadays gaining worldwide acceptance. Historical and traditional uses are extensively documented in ancient texts and historical documents. Black cum... |
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PEGylated-thymoquinone-nanoparticle mediated retardation of breast cancer cell migration by deregulation of cytoskeletal actin polymerization through miR-34a.
Biomaterials 51 , 91-107, (2015) Thymoquinone (TQ), a major active constituent of black seeds of Nigella sativa, has potential medical applications including spectrum of therapeutic properties against different cancers. However, little is known about their effect on breast cancer cell migrat... |
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Effects of natural nuclear factor-kappa B inhibitors on anticancer drug efflux transporter human P-glycoprotein.
Biomed. Pharmacother. 70 , 140-5, (2015) Drug efflux transporter P-glycoprotein plays an important role in cancer chemotherapy. The nuclear factor-κB (NF-κB) transcription factors play critical roles in development and progression of cancer. In this study, the effects of natural compounds that can i... |
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Chemopreventive and therapeutic potentials of thymoquinone in HepG2 cells: mechanistic perspectives.
J. Nat. Med. 69 , 313-23, (2015) Liver cancer is the fifth commonest malignancy worldwide and the third leading cause of death. Identifying novel curative and preventive therapy may improve its prognosis. In this study, thymoquinone (TQ), the most active biological ingredient of Nigella sati... |