Xanthine amine congener
Xanthine amine congener structure
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Common Name | Xanthine amine congener | ||
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| CAS Number | 96865-92-8 | Molecular Weight | 428.48 | |
| Density | 1.262g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C21H28N6O4 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
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Chaperoning of the A1-adenosine receptor by endogenous adenosine - an extension of the retaliatory metabolite concept.
Mol. Pharmacol. 87(1) , 39-51, (2015) Cell-permeable orthosteric ligands can assist folding of G protein-coupled receptors in the endoplasmic reticulum (ER); this pharmacochaperoning translates into increased cell surface levels of receptors. Here we used a folding-defective mutant of human A1-ad... |
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Allosteric interactions across native adenosine-A3 receptor homodimers: quantification using single-cell ligand-binding kinetics.
FASEB J. 25(10) , 3465-76, (2011) A growing awareness indicates that many G-protein-coupled receptors (GPCRs) exist as homodimers, but the extent of the cooperativity across the dimer interface has been largely unexplored. Here, measurement of the dissociation kinetics of a fluorescent agonis... |
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Hyperactivation of D1 and A2A receptors contributes to cognitive dysfunction in Huntington's disease.
Neurobiol. Dis. 74 , 41-57, (2015) Stimulation of dopamine D1 receptor (D1R) and adenosine A2A receptor (A2AR) increases cAMP-dependent protein kinase (PKA) activity in the brain. In Huntington's disease, by essentially unknown mechanisms, PKA activity is increased in the hippocampus of mouse ... |
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Investigation of the functional expression of purine and pyrimidine receptors in porcine isolated pancreatic arteries.
Purinergic Signal. 10(2) , 241-9, (2014) Receptors for purines and pyrimidines are expressed throughout the cardiovascular system. This study investigated their functional expression in porcine isolated pancreatic arteries. Pancreatic arteries (endothelium intact or denuded) were prepared for isomet... |
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Dental pulp stem cells: a new cellular resource for corneal stromal regeneration.
Stem Cells Transl. Med. 4(3) , 276-85, (2015) Corneal blindness afflicts millions of individuals worldwide and is currently treated by grafting with cadaveric tissues; however, there are worldwide donor tissue shortages, and many allogeneic grafts are eventually rejected. Autologous stem cells present a ... |
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Biosensor-based affinities and binding kinetics of small molecule antagonists to the adenosine A(2A) receptor reconstituted in HDL like particles.
FEBS Lett. 589 , 1399-405, (2015) The options for investigating solubilised G protein-coupled receptors (GPCRs) by biophysical techniques have long been hampered by their instability. A thermostabilised adenosine A2A receptor expressed in insect cells, purified in detergent and reconstituted ... |
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Quantitative analysis of the formation and diffusion of A1-adenosine receptor-antagonist complexes in single living cells.
Proc. Natl. Acad. Sci. U. S. A. 101(13) , 4673-8, (2004) The A1-adenosine receptor (A1-AR) is a G protein-coupled receptor that mediates many of the physiological effects of adenosine in the brain, heart, kidney, and adipocytes. Currently, ligand interactions with the A1-AR can be quantified on large cell populatio... |
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Adenosine receptor antagonists and retinal neovascularization in vivo.
Invest. Ophthalmol. Vis. Sci. 42(13) , 3320-4, (2001) The role of adenosine receptor (AdoR) antagonists in human retinal endothelial cell function in vitro has previously been determined. In this study, efficacy of AdoR antagonist administration in reducing retinal neovascularization was examined in a mouse pup ... |
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Adrenomedullin mediates coronary vasodilation through adenosine receptors and KATP channels.
J. Surg. Res. 67(2) , 163-8, (1997) The following experiments were conducted to determine whether, and the mechanisms through which, endogenous peptides alter coronary artery blood flow. Ultrasonic transit time probes were placed around the ascending aorta and left anterior descending coronary ... |
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Antagonist selective modulation of adenosine A1 and A3 receptor pharmacology by the food dye Brilliant Black BN: evidence for allosteric interactions.
Mol. Pharmacol. 77(4) , 678-86, (2010) Allosteric binding sites on the adenosine receptor family represent potential therapeutic targets for a number of conditions involving metabolic stress. This study has identified Brilliant Black BN as a novel allosteric modulator of the adenosine A(1) and A(3... |