PHENCYCLIDINE HYDROCHLORIDE
PHENCYCLIDINE HYDROCHLORIDE structure
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Common Name | PHENCYCLIDINE HYDROCHLORIDE | ||
|---|---|---|---|---|
| CAS Number | 956-90-1 | Molecular Weight | 279.84800 | |
| Density | N/A | Boiling Point | 340ºC at 760 mmHg | |
| Molecular Formula | C17H26ClN | Melting Point | 233-235ºC | |
| MSDS | Chinese USA | Flash Point | 144.5ºC | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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Desformylflustrabromine (dFBr) and [3H]dFBr-Labeled Binding Sites in a Nicotinic Acetylcholine Receptor.
Mol. Pharmacol. 88 , 1-11, (2015) Desformylflustrabromine (dFBr) is a positive allosteric modulator (PAM) of α4β2 and α2β2 nAChRs that, at concentrations >1 µM, also inhibits these receptors and α7 nAChRs. However, its interactions with muscle-type nAChRs have not been characterized, and the ... |
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Behavioral effects of phencyclidine on nicotine self-administration and reinstatement in the presence or absence of a visual stimulus in rats.
Psychopharmacology 232 , 2877-87, (2015) Tobacco use is a serious health problem in the USA, and this problem is potentiated in patients with schizophrenia. The reward system is implicated in schizophrenia and may contribute to the high comorbidity between nicotine use and schizophrenia, but very li... |
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1-aminocyclopropanecarboxylic acid (ACPC) produces procognitive but not antipsychotic-like effects in rats.
Psychopharmacol. Ser. 232(6) , 1025-38, (2015) In addition to the negative and positive symptoms of schizophrenia, cognitive deficits, including prefrontal cortical dysfunction, are now recognized as core features of this disorder. Compounds increasing the NMDA receptor function via the strychnine-insensi... |
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Ontogenetic influence on rat susceptibility to lindane seizure after pretreatment with phencyclidine.
Environ. Toxicol. Pharmacol. 35(2) , 161-70, (2013) The aim of the study was to determine the effects of early postnatal PCP treatment on the sensitivity of pubertal and adult rats to lindane proepileptogenic effects. Rat pups were treated with NaCl (0.9%) or PCP (10 mg/kg) at postnatal days 2, 6, 9 and 12. On... |
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Differential effects of NMDA receptor antagonists at lower and higher doses on basal gamma band oscillation power in rat cortical electroencephalograms.
Neuropharmacology 85 , 384-96, (2014) Schizophrenic patients have been shown to exhibit abnormal cortical gamma band oscillation (GBO), which is thought to be related to the symptoms of schizophrenia, including cognitive impairment. Recently, non-competitive NMDA receptor (NMDAr) antagonists such... |
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Behavioral phenotypes in schizophrenic animal models with multiple combinations of genetic and environmental factors.
J. Pharmacol. Sci. 121(3) , 185-91, (2013) Schizophrenia is a multifactorial psychiatric disorder in which both genetic and environmental factors play a role. Genetic [e.g., Disrupted-in-schizophrenia 1 (DISC1), Neuregulin-1 (NRG1)] and environmental factors (e.g., maternal viral infection, obstetric ... |
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Cariprazine, a dopamine D(3)-receptor-preferring partial agonist, blocks phencyclidine-induced impairments of working memory, attention set-shifting, and recognition memory in the mouse.
Psychopharmacology 226(1) , 91-100, (2013) A major challenge in the pharmacological treatment of psychotic disorders is the effective management of the associated cognitive dysfunctions. Novel concepts emphasize a potential benefit of partial agonists acting upon dopamine D(2)-like receptors in amelio... |
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mGluR5 antagonist-induced psychoactive properties: MTEP drug discrimination, a pharmacologically selective non-NMDA effect with apparent lack of reinforcing properties.
J. Pharmacol. Exp. Ther. 349(1) , 155-64, (2014) Fenobam [N-(3-chlorophenyl)-N'-(4,5-dihydro-1-methyl-4-oxo-1H-imidazole-2-yl)urea], a potent metabotropic glutamate mGluR5 receptor antagonist, reported to have analgesic effects in animals and anxiolytic effects in humans, also caused adverse events, includi... |
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Differential effects of subchronic phencyclidine on anxiety in the light-enhanced startle-, light/dark exploration- and open field tests.
Behav. Brain Res. 243 , 61-5, (2013) Subchronic treatment with the N-methyl-d-aspartate receptor antagonist phencyclidine (PCP) is a valuable approach to model the symptomatology of schizophrenia, a multi-facetted psychiatric disorder, in rodents. We addressed the question whether subchronic PCP... |
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How often do false-positive phencyclidine urine screens occur with use of common medications?
Clin. Toxicol. (Phila.) 51(6) , 493-6, (2013) Previous reports describe false-positive urine immunoassay screens for phencyclidine (PCP) associated with use of tramadol, dextromethorphan, or diphenhydramine. The likelihood of these false positives is unknown.We sought to find the relative frequency of fa... |