dorsomorphin
dorsomorphin structure
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Common Name | dorsomorphin | ||
|---|---|---|---|---|
| CAS Number | 866405-64-3 | Molecular Weight | 399.488 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C24H25N5O | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Regulation of insulin-like growth factor signaling by metformin in endometrial cancer cells.
Oncol. Lett. 8(5) , 1993-1999, (2014) Obesity, diabetes and insulin resistance are marked risk factors that promote the development of type I endometrial cancer. Previous studies have demonstrated that insulin-like growth factor 1 (IGF-1) and IGF-2 promote cell proliferation in endometrial cancer... |
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The PRKAA1/AMPKα1 pathway triggers autophagy during CSF1-induced human monocyte differentiation and is a potential target in CMML.
Autophagy 11 , 1114-29, (2015) Autophagy is induced during differentiation of human monocytes into macrophages that is mediated by CSF1/CSF-1/M-CSF (colony stimulating factor 1 [macrophage]). However, little is known about the molecular mechanisms that link CSF1 receptor engagement to the ... |
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Alpha-lipoic acid activates eNOS through activation of PI3-kinase/Akt signaling pathway.
Vascul. Pharmacol. 64 , 28-35, (2015) Lipoic acid (LA) exerts therapeutic effects on cardiovascular diseases. However, the mechanisms underlying these therapeutic effects remain elusive. Endothelial nitric oxide synthase (eNOS) plays a critical role in cardiovascular homeostasis. LA was shown to ... |
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Metformin promotes irisin release from murine skeletal muscle independently of AMP-activated protein kinase activation.
Acta Physiol. (Oxf.) 213(3) , 711-21, (2015) Irisin, a novel myocyte-secreted hormone mediating beneficial effects of exercise on metabolism, is supposed to be an ideal therapeutic target for metabolic disorders such as obesity and diabetes. Here, we investigated the potential effects of metformin and g... |
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Stimulatory Effects of Balanced Deep Sea Water on Mitochondrial Biogenesis and Function.
PLoS ONE 10 , e0129972, (2015) The worldwide prevalence of metabolic diseases, including obesity and diabetes, is increasing. Mitochondrial dysfunction is recognized as a core feature of these diseases. Emerging evidence also suggests that defects in mitochondrial biogenesis, number, morph... |
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Developmental regulation of tau splicing is disrupted in stem cell-derived neurons from frontotemporal dementia patients with the 10 + 16 splice-site mutation in MAPT.
Hum. Mol. Genet. 24 , 5260-9, (2015) The alternative splicing of the tau gene, MAPT, generates six protein isoforms in the adult human central nervous system (CNS). Tau splicing is developmentally regulated and dysregulated in disease. Mutations in MAPT that alter tau splicing cause frontotempor... |
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A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors.
Arch. Toxicol. 89 , 1599-618, (2015) Test systems to identify developmental toxicants are urgently needed. A combination of human stem cell technology and transcriptome analysis was to provide a proof of concept that toxicants with a related mode of action can be identified and grouped for read-... |
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Adiponectin prevents reduction of lipid-induced mitochondrial biogenesis via AMPK/ACC2 pathway in chicken adipocyte.
J. Cell. Biochem. 116(6) , 1090-100, (2015) Adiponectin (APN) stimulates mitochondrial biogenesis and reduces lipid content in human and animal adipocytes. However, the mechanism of adiponectin in regulating mitochondrial biogenesis in chicken adipocytes has never been reported. The objective of this s... |
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Co-operative Bmp- and Fgf-signaling inputs convert skin wound healing to limb formation in urodele amphibians.
Dev. Biol. 396(1) , 57-66, (2014) Urodele amphibians have remarkable organ regeneration capability, and their limb regeneration capability has been investigated as a representative phenomenon. In the early 19th century, nerves were reported to be an essential tissue for the successful inducti... |
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Rapid and robust generation of long-term self-renewing human neural stem cells with the ability to generate mature astroglia.
Sci. Rep. 5 , 16321, (2015) Induced pluripotent stem cell bear the potential to differentiate into any desired cell type and hold large promise for disease-in-a-dish cell-modeling approaches. With the latest advances in the field of reprogramming technology, the generation of patient-sp... |