Cyclosomatostatin
Cyclosomatostatin structure
|
Common Name | Cyclosomatostatin | ||
|---|---|---|---|---|
| CAS Number | 84211-54-1 | Molecular Weight | 779.96700 | |
| Density | 1.147g/cm3 | Boiling Point | 1118.4ºC at 760 mmHg | |
| Molecular Formula | C44H57N7O6 | Melting Point | N/A | |
| MSDS | USA | Flash Point | 630.2ºC | |
|
Frequency-dependent, cell type-divergent signaling in the hippocamposeptal projection.
J. Neurosci. 34(35) , 11769-80, (2014) Hippocampal oscillations are critical for information processing, and are strongly influenced by inputs from the medial septum. Hippocamposeptal neurons provide direct inhibitory feedback from the hippocampus onto septal cells, and are therefore likely to als... |
|
|
Effects of somatostatin on the responses of rostrally projecting spinal dorsal horn neurons to noxious stimuli in cats.
Korean J. Physiol. Pharmacol. 12(5) , 253-8, (2008) Somatostatin (SOM) is a widely distributed peptide in the central nervous system and exerts a variety of hormonal and neural actions. Although SOM is assumed to play an important role in spinal nociceptive processing, its exact function remains unclear. In fa... |
|
|
Oral curcumin has anti-arthritic efficacy through somatostatin generation via cAMP/PKA and Ca(2+)/CaMKII signaling pathways in the small intestine.
Pharmacol. Res. 95-96 , 71-81, (2015) Curcumin (CUR) has been proven to be clinically effective in rheumatoid arthritis (RA) therapy, but its low oral bioavailability eclipses existent evidence that attempts to explain the underlying mechanism. Small intestine, the only organ exposed to a relativ... |
|
|
Effects of gamma-aminobutyric acid on secretagogue-induced exocrine secretion of isolated, perfused rat pancreas.
Am. J. Physiol. Gastrointest. Liver Physiol. 279(4) , G677-82, (2000) Because GABA and its related enzymes have been determined in beta-cells of pancreas islets, effects of GABA on pancreatic exocrine secretion were investigated in the isolated, perfused rat pancreas. GABA, given intra-arterially at concentrations of 3, 10, 30,... |
|
|
Galanin potentiates supramaximal caerulein-stimulated pancreatic amylase secretion via its action on somatostatin secretion.
Am. J. Physiol. Gastrointest. Liver Physiol. 297(6) , G1268-73, (2009) Galanin inhibits pancreatic amylase secretion from mouse lobules induced by physiological concentrations of caerulein via an insulin-dependent mechanism. We aimed to determine the effect and elucidate the mechanism of action of exogenous galanin on pancreatic... |
|
|
Attenuation of the reflex responses to muscle contraction by the coadministration of antagonists to substance P and somatostatin into the dorsal horn.
Cardiovasc. Res. 29(3) , 379-84, (1995) The aim was to determine if the coadministration of antagonists to substance P and somatostatin into the L7 dorsal horn blunts the reflex cardiovascular responses to static contraction to a greater extent than each antagonist alone. The possibility that this ... |
|
|
Anti-somatostatin antisera, but neither a somatostatin agonist (octreotide) nor antagonist (CYCAM), attenuates hyperalgesia in the rat.
Peptides 17(5) , 769-73, (1996) Somatostatin has been reported to have both nociceptive and antinociceptive roles in sensory transmission in the spinal cord. In this study, antisera against SOM (alpha-SOM), a somatostatin antagonist (CYCAM) and a somatostatin agonist (octreotide), were eval... |
|
|
Somatostatin inhibits the release of noradrenaline induced by electrical stimulation of the rat mesenteric artery.
Pharmacol. Res. 41(4) , 497-501, (2000) Somatostatin, a peptide with antisecretory and antiproliferative effects, coexists with noradrenaline in sympathetic neurons. Octreotide, a stable somatostatin analogue, prevents hypertension and cardiovascular structural changes induced by prolonged infusion... |
|
|
Somatostatin modulates Ca2+ currents in neostriatal neurons.
Neuroscience 109(3) , 555-67, (2002) Somatostatin is synthesized and released by aspiny interneurons of the neostriatum. This work investigates the actions of somatostatin on rat neostriatal neurons of medium size (ca. 6 pF). Somatostatin (1 microM) reduces both calcium action potentials (20 mM ... |
|
|
Effects of intrapancreatic neuronal activation on cholecystokinin-induced exocrine secretion of isolated perfused rat pancreas.
Pflugers Arch. 437(4) , 511-6, (1999) The role of intrapancreatic neurons in the action of cholecystokinin (CCK) on pancreatic exocrine secretion of the totally isolated, perfused rat pancreas was investigated. Intrapancreatic neurons were activated by applying electrical field stimulation (EFS) ... |