IWP-2
IWP-2 structure
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Common Name | IWP-2 | ||
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| CAS Number | 686770-61-6 | Molecular Weight | 466.599 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C22H18N4O2S3 | Melting Point | 257 °C(dec.) | |
| MSDS | USA | Flash Point | N/A | |
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Ligand-independent canonical Wnt activity in canine mammary tumor cell lines associated with aberrant LEF1 expression.
PLoS ONE 9(6) , e98698, (2014) Pet dogs very frequently develop spontaneous mammary tumors and have been suggested as a good model organism for breast cancer research. In order to obtain an insight into underlying signaling mechanisms during canine mammary tumorigenesis, in this study we a... |
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Notch inhibition induces mitotically generated hair cells in mammalian cochleae via activating the Wnt pathway.
Proc. Natl. Acad. Sci. U. S. A. 112(1) , 166-71, (2015) The activation of cochlear progenitor cells is a promising approach for hair cell (HC) regeneration and hearing recovery. The mechanisms underlying the initiation of proliferation of postnatal cochlear progenitor cells and their transdifferentiation to HCs re... |
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A switch from canonical to noncanonical Wnt signaling mediates early differentiation of human neural stem cells.
Stem Cells 32(12) , 3196-208, (2014) Wnt/β-catenin signaling is essential for neurogenesis but less is known about β-catenin-independent Wnt signals. We show here that Wnt/activator protein-1 (AP-1) signaling drives differentiation of human embryonic stem cell and induced pluripotent stem cell-d... |
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Up-regulation of BMP2/4 signaling increases both osteoblast-specific marker expression and bone marrow adipogenesis in Gja1Jrt/+ stromal cell cultures.
Mol. Biol. Cell 26(5) , 832-42, (2015) Gja1(Jrt)/+ mice carry a mutation in one allele of the gap junction protein α1 gene (Gja1), resulting in a G60S connexin 43 (Cx43) mutant protein that is dominant negative for Cx43 protein production of <50% of wild-type (WT) levels and significantly reduced ... |
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A systems-biological study on the identification of safe and effective molecular targets for the reduction of ultraviolet B-induced skin pigmentation.
Sci. Rep. 5 , 10305, (2015) Melanogenesis is the process of melanin synthesis through keratinocytes-melanocytes interaction, which is triggered by the damaging effect of ultraviolet-B (UVB) rays. It is known that melanogenesis influences diverse cellular responses, including cell surviv... |
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Regulation of metastasis of bladder cancer cells through the WNT signaling pathway.
Tumour Biol. 36 , 8839-44, (2015) Bladder cancer (BC) is the most popular malignant urinary cancer, with the highest incidence and mortality of all genitourinary system tumors worldwide. To date, the molecular regulation of the metastasis of BC remains ill defined. Here, we examined the level... |