Nicotine ditartrate
Nicotine ditartrate structure
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Common Name | Nicotine ditartrate | ||
|---|---|---|---|---|
| CAS Number | 65-31-6 | Molecular Weight | 462.405 | |
| Density | N/A | Boiling Point | 508ºC(e) | |
| Molecular Formula | C18H26N2O12 | Melting Point | 89ºC | |
| MSDS | Chinese USA | Flash Point | 101.7ºC | |
| Symbol |
GHS06, GHS09 |
Signal Word | Danger | |
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A concurrent excitation and inhibition of dopaminergic subpopulations in response to nicotine.
Sci. Rep. 5 , 8184, (2015) Midbrain dopamine (DA) neurons are key players in motivation and reward processing. Increased DA release is thought to be central in the initiation of drug addiction. Whereas dopamine neurons are generally considered to be activated by drugs such as nicotine,... |
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Inhibition of monoacylglycerol lipase reduces nicotine withdrawal.
Br. J. Pharmacol. 172(3) , 869-82, (2015) Abrupt discontinuation of nicotine, the main psychoactive component in tobacco, induces a withdrawal syndrome in nicotine-dependent animals, consisting of somatic and affective signs, avoidance of which contributes to drug maintenance. While blockade of fatty... |
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Orally administered nicotine induces urothelial hyperplasia in rats and mice.
Toxicology 315 , 49-54, (2014) Tobacco smoking is a major risk factor for multiple human cancers including urinary bladder carcinoma. Tobacco smoke is a complex mixture containing chemicals that are known carcinogens in humans and/or animals. Aromatic amines a major class of DNA-reactive c... |
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Novel Striatal GABAergic Interneuron Populations Labeled in the 5HT3a(EGFP) Mouse.
Cereb. Cortex 26 , 96-105, (2015) Histological and morphological studies indicate that approximately 5% of striatal neurons are cholinergic or γ-aminobutyric acidergic (GABAergic) interneurons (gINs). However, the number of striatal neurons expressing known interneuron markers is too small to... |
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Neuroanatomical circuitry mediating the sensory impact of nicotine in the central nervous system.
J. Neurosci. Res. 93(2) , 230-43, (2015) Direct actions of nicotine in the CNS appear to be essential for its reinforcing properties. However, activation of nicotinic acetylcholine receptors (nAChRs) on afferent sensory nerve fibers is an important component of addiction to, and withdrawal from, cig... |
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Impact of chronic nicotine administration on bone mineral content in young and adult rats: a comparative study.
Eur. J. Pharmacol. 720(1-3) , 1-6, (2013) The aim of this study was to evaluate the effects of chronic nicotine administration on bone mineral homeostasis in rapidly growing young rats in comparison to effects in adult male rats. Two doses of nicotine (3 and 4.5mg/kg/day, as nicotine hydrogen tartrat... |
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Partial blockade of nicotinic acetylcholine receptors improves the counterregulatory response to hypoglycemia in recurrently hypoglycemic rats.
Am. J. Physiol. Endocrinol. Metab. 307(7) , E580-8, (2014) Recurrent exposure to hypoglycemia can impair the normal counterregulatory hormonal responses that guard against hypoglycemia, leading to hypoglycemia unawareness. This pathological condition known as hypoglycemia-associated autonomic failure (HAAF) is the ma... |
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Reinforcing and neural activating effects of norharmane, a non-nicotine tobacco constituent, alone and in combination with nicotine.
Neuropharmacology 85 , 293-304, (2014) Tobacco use is the leading cause of preventable death. Although the health risks are well known, cessation rates remain low. Whereas behavioral and neuroanatomical studies on tobacco addiction conventionally use nicotine, there is evidence that other constitu... |
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Proteomics reveals potential non-neuronal cholinergic receptor-effectors in endothelial cells.
Acta Pharmacol. Sin. 35(9) , 1137-49, (2014) The non-neuronal acetylcholine system (NNAS) in endothelial cells participates in modulating endothelial function, vascular tone, angiogenesis and inflammation, thus plays a critical role in cardiovascular diseases. In this study, we used a proteomic approach... |
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Effects of the nicotinic acetylcholine receptor antagonist mecamylamine on the discriminative stimulus effects of cocaine in male rhesus monkeys.
Exp. Clin. Psychopharmacol. 22(3) , 266-73, (2014) Preclinical drug discrimination procedures have been useful in understanding the pharmacological mechanisms of the subjective-like effects of abused drugs. Converging lines of evidence from neurochemical and behavioral studies implicate a potential role of ni... |