OXPRENOLOL HYDROCHLORIDE
OXPRENOLOL HYDROCHLORIDE structure
|
Common Name | OXPRENOLOL HYDROCHLORIDE | ||
|---|---|---|---|---|
| CAS Number | 6452-73-9 | Molecular Weight | 301.80900 | |
| Density | N/A | Boiling Point | 403.3ºC at 760 mmHg | |
| Molecular Formula | C15H24ClNO3 | Melting Point | 178°C | |
| MSDS | N/A | Flash Point | 197.7ºC | |
|
Determination of selected beta-receptor antagonists in biological samples by solid-phase extraction with cholesterolic phase and LC/MS.
Anal. Bioanal. Chem 393(1) , 263-72, (2009) A new method is presented for the determination of five selected beta-receptor antagonists by HPLC, which emphasizes sample preparation via retention on a new type of silica gel sorbent used for solid-phase extraction (SPE). Sorbents of this type were obtaine... |
|
|
Quantitative determination of oxprenolol and timolol in urine by capillary zone electrophoresis.
J. Chromatogr. A. 949(1-2) , 91-7, (2002) A simple capillary zone electrophoretic method with UV detection has been developed for the quantitative determination of the beta-adrenoreceptor antagonists (beta-blockers) oxprenolol and timolol in human urine, preceded by a solid-phase extraction step. The... |
|
|
Iontophoretic in vivo transdermal delivery of beta-blockers in hairless rats and reduced skin irritation by liposomal formulation.
Pharm. Res. 20(9) , 1496-501, (2003) To demonstrate the in vivo transdermal delivery and establish the comparative pharmacokinetics of five beta-blockers in hairless rat.Intravenous dosing was initially done via jugular cannula. For iontophoretic delivery, current (0.1 mA/cm2) was applied for 2 ... |
|
|
High sensitivity analysis of oxprenolol in urine by capillary electrophoresis with C18 packed on-line preconcentrator.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 839(1-2) , 6-11, (2006) High sensitivity analysis of oxprenolol in spiked human urine has been performed by capillary zone electrophoresis (CZE) in ammonium formate buffer pH 2.5 using an uncoated capillary with 1cm length C18 on-capillary preconcentrator at the inlet side. The prec... |
|
|
High frequency controlled capsules with integrated gas producing cells.
Eur. J. Pharm. Biopharm. 72(1) , 282-4, (2009) In the present investigations, a new high frequency remote-controlled capsule has been developed in which the mechanical energy to empty a drug reservoir is generated by a miniature gas producing cell. If the poles of the gas producing cell are connected by a... |
|
|
Enantiomeric separation by using nano-liquid chromatography with on-column focusing.
J. Sep. Sci. 31(14) , 2567-71, (2008) The present study shows a new nano-liquid chromatographic method for beta-blocker enantiomers' separation. This method consists of using a capillary column packed with silica particles which were chemically modified with vancomycin. On-column focusing allowed... |
|
|
Oxprenolol hydrochloride: pharmacology, pharmacokinetics, adverse effects and clinical efficacy.
Pharmacotherapy 3(2 Pt 1) , 68-81, (1983) Oxprenolol is a nonselective beta-adrenergic blocking agent that also possesses intrinsic sympathomimetic activity (ISA) and membrane stabilizing effects. Oxprenolol undergoes first pass metabolism with only 30% of an oral dose reaching the systemic circulati... |
|
|
Quantitative determination of propranolol by ultraviolet HPLC in human plasma.
Toxicol. Mech. Methods 20(3) , 137-42, (2010) Many previous published methods for the quantitative determination of propranolol (PRN) in human plasma have poor recoveries and were not validated according to the FDA guideline. The aim of this study is to develop a simple HPLC method for detecting PRN in h... |
|
|
[Medium sized rings from alprenolol and oxprenolol].
Pharmazie 59(10) , 763-9, (2004) The N-allyl derivatives 2 formed from the beta-blockers 1, were acetylated to give the esters 5. The 1,5-benzoxazacycloundecine 6a and the 1,10,5-benzodioxazacyclododecine 7a were isolated by ring closing metathesis (RCM) of 5a and 5b, respectively, using Gru... |
|
|
[Bromometric assay of alprenolol and oxprenolol].
Pharmazie 59(9) , 678-82, (2004) Alprenolol (1a) reacts with an excess of bromine to yield the tribromo derivative 3a by addition and monosubstitution, while applying oxprenolol (1b) the disubstituted tetrabromo derivative 2b is obtained. The N-dealkylated substance 3c was isolated as a by-p... |