Pharmazie 2004-10-01

[Medium sized rings from alprenolol and oxprenolol].

K Görlitzer, A Lorenz

Index: Pharmazie 59(10) , 763-9, (2004)

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Abstract

The N-allyl derivatives 2 formed from the beta-blockers 1, were acetylated to give the esters 5. The 1,5-benzoxazacycloundecine 6a and the 1,10,5-benzodioxazacyclododecine 7a were isolated by ring closing metathesis (RCM) of 5a and 5b, respectively, using Grubbs catalyst in the presence of titanium tetraisopropanolate. Alkaline hydrolysis yielded the alcohols 6b and 7b.