Cannabinol
Cannabinol structure
|
Common Name | Cannabinol | ||
|---|---|---|---|---|
| CAS Number | 521-35-7 | Molecular Weight | 310.43000 | |
| Density | 1.061 g/cm3 | Boiling Point | 476.5ºC at 760 mmHg | |
| Molecular Formula | C21H26O2 | Melting Point | 76 - 77ºC | |
| MSDS | Chinese USA | Flash Point | 212.7ºC | |
| Symbol |
GHS02, GHS06, GHS08 |
Signal Word | Danger | |
|
Pressurized liquid extraction for the determination of cannabinoids and metabolites in hair: Detection of cut-off values by high performance liquid chromatography-high resolution tandem mass spectrometry.
J. Chromatogr. A. 1406 , 192-200, (2015) Hair analysis has become a routine procedure in most forensic laboratories since this alternative matrix presents clear advantages over classical matrices; particularly wider time window, non-invasive sampling and good stability of the analytes over time. The... |
|
|
Involvement of UDP-glucuronosyltransferases UGT1A9 and UGT2B7 in ethanol glucuronidation, and interactions with common drugs of abuse.
Drug Metab. Dispos. 41(3) , 568-74, (2013) Ethyl glucuronide (EtG) determination is increasingly used in clinical and forensic toxicology to document ethanol consumption. The enzymes involved in EtG production, as well as potential interactions with common drugs of abuse, have not been extensively stu... |
|
|
Simultaneous identification of 2-carboxy-tetrahydrocannabinol, tetrahydrocannabinol, cannabinol and cannabidiol in oral fluid.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 852(1-2) , 459-64, (2007) Tetrahydrocannabinol (THC) is an important psychoactive ingredient in marijuana, which is the most widely used illegal recreational drug in the USA. Since it is generally smoked, the constituents of the plant material, as well as THC may be present in oral fl... |
|
|
Acute effects of Delta9-tetrahydrocannabinol and standardized cannabis extract on the auditory evoked mismatch negativity.
Schizophr. Res. 97(1-3) , 109-17, (2007) Reduced amplitudes of auditory evoked mismatch negativity (MMN) have often been found in schizophrenic patients, indicating deficient auditory information processing and working memory. Cannabis-induced psychotic states may resemble schizophrenia. Currently, ... |
|
|
Evaluation of principal cannabinoids in airborne particulates.
Anal. Chim. Acta 641(1-2) , 89-94, (2009) The determination of delta(9)-tetrahydrocannabinol (Delta9-THC), cannabidiol (CND) and cannabinol (CNB), primary active components in cannabis preparation, was carried out on airborne particulates by applying a specific procedure consisting of soot extraction... |
|
|
Comparison in the in vitro inhibitory effects of major phytocannabinoids and polycyclic aromatic hydrocarbons contained in marijuana smoke on cytochrome P450 2C9 activity.
Drug Metab. Pharmacokinet. 27(3) , 294-300, (2012) Inhibitory effects of Δ⁹-tetrahydrocannabinol (Δ⁹-THC), cannabidiol (CBD), and cannabinol (CBN), the three major constituents in marijuana, and polycyclic aromatic hydrocarbons (PAHs) contained in marijuana smoke on catalytic activity of human cytochrome P450... |
|
|
Novel hexahydrocannabinol analogs as potential anti-cancer agents inhibit cell proliferation and tumor angiogenesis.
Eur. J. Pharmacol. 650(1) , 64-71, (2011) Both natural and synthetic cannabinoids have been shown to suppress the growth of tumor cells in culture and in animal models by affecting key signaling pathways including angiogenesis, a pivotal step in tumor growth, invasion, and metastasis. In our search f... |
|
|
Potent inhibition of human cytochrome P450 3A isoforms by cannabidiol: role of phenolic hydroxyl groups in the resorcinol moiety.
Life Sci. 88(15-16) , 730-6, (2011) In this study, we examined the inhibitory effects of Δ(9)-tetrahydrocannabinol (Δ(9)-THC), cannabidiol (CBD), and cannabinol (CBN), the three major cannabinoids, on the activity of human cytochrome P450 (CYP) 3A enzymes. Furthermore, we investigated the kinet... |
|
|
Cannabinol and cannabidiol exert opposing effects on rat feeding patterns.
Psychopharmacology 223(1) , 117-29, (2012) Increased food consumption following ∆(9)-tetrahydrocannabinol-induced cannabinoid type 1 receptor agonism is well documented. However, possible non-∆(9)-tetrahydrocannabinol phytocannabinoid-induced feeding effects have yet to be fully investigated. Therefor... |
|
|
High-pressure-promoted Diels-Alder approach to biaryls: application to the synthesis of the cannabinols family.
J. Org. Chem. 77(18) , 7923-31, (2012) Diels-Alder reactions of a range of 1-(alkoxy/alkyl/halogen-substituted phenyl)buta-1,3-dienes with methyl propiolate carried out in a green ethanolic medium under 9 kbar pressure were investigated. The use of high pressure as activating method of the Diels-A... |