Benzol-1,2,4,5-tetramintetrahydrochlorid
Benzol-1,2,4,5-tetramintetrahydrochlorid structure
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Common Name | Benzol-1,2,4,5-tetramintetrahydrochlorid | ||
|---|---|---|---|---|
| CAS Number | 4506-66-5 | Molecular Weight | 284.014 | |
| Density | N/A | Boiling Point | 400.9ºC at 760mmHg | |
| Molecular Formula | C6H14Cl4N4 | Melting Point | ≥300ºC(lit.) | |
| MSDS | Chinese USA | Flash Point | 233.6ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Down-regulation of ALDH1A3, CD44 or MDR1 sensitizes resistant cancer cells to FAK autophosphorylation inhibitor Y15.
J. Cancer Res. Clin. Oncol. 141 , 1613-31, (2015) Focal adhesion kinase is an important survival signal in cancer. Recently, we demonstrated that the autophosphorylation inhibitor of FAK, Y15, effectively inhibited cancer cell growth. We detected many cancer cell lines sensitive to Y15 and also detected seve... |
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FAK is a critical regulator of neuroblastoma liver metastasis.
Oncotarget 3 , 1576-87, (2013) Neuroblastomas express increased levels of gastrin-releasing peptide receptor (GRP-R). However, the exact molecular mechanisms involved in GRP-R-mediated cell signaling in neuroblastoma growth and metastasis are unknown. Here, we report that focal adhesion ki... |
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CEACAM6 promotes tumor angiogenesis and vasculogenic mimicry in gastric cancer via FAK signaling.
Biochim. Biophys. Acta 1852(5) , 1020-8, (2015) CEACAM6 is a member of glycosylphosphatidylinositol-linked immunoglobulin superfamily that is implicated in a variety of human cancers. In our previous study, we reported that CEACAM6 was overexpressed in gastric cancer tissues and promoted cancer metastasis.... |
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In vivo toxicity, metabolism and pharmacokinetic properties of FAK inhibitor 14 or Y15 (1, 2, 4, 5-benzenetetramine tetrahydrochloride).
Arch. Toxicol. 89 , 1095-101, (2015) Y15 or inhibitor 14 (1,2,4,5-benzenetetramine tetrahydrochloride) is a potent and specific inhibitor of focal adhesion kinase that inhibits its autophosphorylation activity, decreases the viability of cancer cells, and blocks tumor growth. In this preclinical... |
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Involvement of TGFβ-induced phosphorylation of the PTEN C-terminus on TGFβ-induced acquisition of malignant phenotypes in lung cancer cells.
PLoS ONE 8 , e81133, (2013) Transforming growth factor β (TGFβ) derived from the tumor microenvironment induces malignant phenotypes such as epithelial-mesenchymal transition (EMT) and aberrant cell motility in lung cancers. TGFβ-induced translocation of β-catenin from E-cadherin comple... |
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Suppression of uPAR retards radiation-induced invasion and migration mediated by integrin β1/FAK signaling in medulloblastoma.
PLoS ONE 5 , e13006, (2010) Despite effective radiotherapy for the initial stages of cancer, several studies have reported the recurrence of various cancers, including medulloblastoma. Here, we attempt to capitalize on the radiation-induced aggressive behavior of medulloblastoma cells b... |
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Focal adhesion remodeling is crucial for glucose-stimulated insulin secretion and involves activation of focal adhesion kinase and paxillin.
Diabetes 60(4) , 1146-57, (2011) Actin cytoskeleton remodeling is known to be involved in glucose-stimulated insulin secretion (GSIS). We have observed glucose-stimulated changes at the β-cell basal membrane similar to focal adhesion remodeling in cell migration. This led us to study the rol... |