PD 146176
PD 146176 structure
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Common Name | PD 146176 | ||
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| CAS Number | 4079-26-9 | Molecular Weight | 237.32 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 485.4±24.0 °C at 760 mmHg | |
| Molecular Formula | C15H11NS | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 247.4±22.9 °C | |
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Absence of glutathione peroxidase 4 affects tumor angiogenesis through increased 12/15-lipoxygenase activity.
Neoplasia 12 , 254-63, (2010) The selenoenzyme glutathione peroxidase 4 (GPx4) has been described to control specific cyclooxygenases (COXs) and lipoxygenases (LOXs) that exert substantiated functions in tumor growth and angiogenesis. Therefore, we hypothesized a putative regulatory role ... |
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An enzyme that inactivates the inflammatory mediator leukotriene b4 restricts mycobacterial infection.
PLoS ONE 8 , e67828, (2013) While tuberculosis susceptibility has historically been ascribed to failed inflammation, it is now known that an excess of leukotriene A4 hydrolase (LTA4H), which catalyzes the final step in leukotriene B4 (LTB4) synthesis, produces a hyperinflammatory state ... |
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