DC Chemicals Limited
China
Product Name: PD-146176
Price: $Inquiry/100mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: PD-146176
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: [1]Benzothiopyrano[4,3-b]indole,6,11-dihydro-
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

4079-26-9

4079-26-9 structure

Name: PD 146176
Chemical Name: 6,11-dihydrothiochromeno[4,3-b]indole
CAS Number: 4079-26-9
Molecular Formula: C₁₅H₁₁NS
Molecular Weight: 237.32
Catalog: Signaling Pathways Autophagy Autophagy
Create Date: 2017-01-31 06:48:10
Modify Date: 2025-08-25 17:49:22
PD146176 (NSC168807) is a 15-Lipoxygenase (15-LO) inhibitor, which inhibits rabbit reticulocyte 15-LO with a Ki of 197 nM. PD146176 (NSC168807) has a dramatic effect in reducing atherogenesis[1].

Name	6,11-dihydrothiochromeno[4,3-b]indole
Synonyms	indole<3,2-c>-1-thiochromen 6,11-Dihydro<benzothiopyrano<6,3-b]indole 6,11-Dihydro-<1>benzothiopyrano-<4,3-b>indol 6,11-Dihydro[1]benzothiopyrano[4,3-b]indole 6,11-Dihydrothiochromeno[4,3-b]indole 6,11-dihydro-5-thia-11-aza-benzo(a)-fluorene [1]Benzothiopyrano[4,3-b]indole, 6,11-dihydro- NAN-190 hydrobromide 6,11-Dihydro-benzo<b>indolo<2,3-d>thiopyran

Description	PD146176 (NSC168807) is a 15-Lipoxygenase (15-LO) inhibitor, which inhibits rabbit reticulocyte 15-LO with a Ki of 197 nM. PD146176 (NSC168807) has a dramatic effect in reducing atherogenesis[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Autophagy >> Autophagy
Target	Ki: 197 nM (Rabbit reticulocyte 15-LO)[1]
References	[1]. Sendobry SM, et al. Attenuation of diet-induced atherosclerosis in rabbits with a highly selective 15-lipoxygenaseinhibitor lacking significant antioxidant properties. Br J Pharmacol. 1997 Apr;120(7):1199-206.

Density	1.3±0.1 g/cm3
Boiling Point	485.4±24.0 °C at 760 mmHg
Molecular Formula	C₁₅H₁₁NS
Molecular Weight	237.32
Flash Point	247.4±22.9 °C
Exact Mass	237.061218
PSA	41.09000
LogP	4.38
Vapour Pressure	0.0±1.2 mmHg at 25°C
Index of Refraction	1.774

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport
HS Code	2934999090

121113-04-0

~77%

4079-26-9

Literature: Kidwai, M. M.; Ahluwalia, V. K. Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1988 , vol. 27, # 1-12 p. 962

3528-17-4

100-63-0

4079-26-9

Literature: Kucherova,N.F. et al. J. Gen. Chem. USSR (Engl. Transl.), 1963 , vol. 33, p. 3662 - 3667,3593 - 3597

3528-17-4

4079-26-9

Literature: Kiang; Mann Journal of the Chemical Society, 1951 , p. 1909,1913

5219-65-8

4079-26-9

Literature: Kiang; Mann Journal of the Chemical Society, 1951 , p. 1909,1913

7647-01-0

64-17-5

121113-04-0

4079-26-9

Literature: Kiang; Mann Journal of the Chemical Society, 1951 , p. 1909,1913

Precursor 6
121113-04-0 3528-17-4 100-63-0 5219-65-8
7647-01-0 64-17-5
DownStream 0

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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