DSP-4
DSP-4 structure
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Common Name | DSP-4 | ||
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| CAS Number | 40616-75-9 | Molecular Weight | 313.06100 | |
| Density | 1.338g/cm3 | Boiling Point | 276.7ºC at 760 mmHg | |
| Molecular Formula | C11H16BrCl2N | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
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Noradrenergic terminals regulate L-DOPA-derived dopamine extracellular levels in a region-dependent manner in Parkinsonian rats.
CNS Neurosci. Ther. 20(7) , 671-8, (2014) Serotonin (5-HT) neurons mediate the ectopic release of dopamine (DA) induced by L-DOPA in the Parkinsonian brain. We hypothesized that the participation of noradrenalin transporters (NET) in the clearance of DA may account for the lower effect of L-DOPA in e... |
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c-Fos activity mapping reveals differential effects of noradrenaline and serotonin depletion on the regulation of ocular dominance plasticity in rats.
Neuroscience 235 , 1-9, (2013) The roles of the central noradrenergic and serotonergic system in the activity-dependent regulation of ocular dominance plasticity have been a contentious issue. Using c-Fos activity mapping, we have developed a new, straightforward method to measure the stre... |
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Effects of noradrenaline and serotonin depletions on the neuronal activity of globus pallidus and substantia nigra pars reticulata in experimental parkinsonism.
Neuroscience 202 , 424-33, (2012) Parkinson's disease (PD) is characterized by a degeneration of dopaminergic neurons and also by a degradation of noradrenergic neurons from the locus coeruleus and serotonergic neurons from the dorsal raphe. However, the effect of these depletions on the neur... |
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Cytochrome P450 is regulated by noradrenergic and serotonergic systems.
Pharmacol. Res. 64(4) , 371-80, (2011) The aim of the present study was to ascertain whether the noradrenergic or serotonergic systems may affect the expression of liver cytochrome P450 (CYP). Rats were injected intraperitoneally with N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4, a noradren... |
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Antinociceptive effects of neurotropin in a rat model of central neuropathic pain: DSP-4 induced noradrenergic lesion.
Neurosci. Lett. 503(1) , 20-2, (2011) Neurotropin is a nonprotein extract isolated from inflamed skin of rabbits inoculated with vaccinia virus, and used for treatment of neuropathic pain. In the present study, we have determined whether neurotropin could exert antinociceptive action using the ce... |
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A central neuropathic pain model by DSP-4 induced lesion of noradrenergic neurons: preliminary report.
Neurosci. Lett. 481(2) , 102-4, (2010) Neuropathic pain models are classified as central and peripheral pain models. Although various peripheral neuropathic pain models are established, central pain models are based only on spinal cord injury. DSP-4 is a competitive inhibitor of norepinephrine upt... |
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Gender effect on the accumulation of hyperphosphorylated tau in the brain of locus-ceruleus-injured APP-transgenic mouse.
Neurosci. Lett. 468(3) , 243-7, (2010) Locus ceruleus (LC) neurons are preferentially and initially affected in Alzheimer disease (AD); however, the impact of the loss of LC neurons on the pathological sequence of AD, including amyloid beta-protein (Abeta) deposition and neurofibrillary tangle for... |
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Effect of DSP-4 induced central noradrenergic depletion on tactile learning in rat.
Neurol. Res. 34(1) , 80-4, (2012) There is general agreement that norepinephrine could modulate neuronal responses to non-monoaminergic synaptic inputs in the somatosensory cortex. In the present study, we investigated the effect of central norepinephrine depletion on tactile learning in rats... |
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Role of coerulean noradrenergic neurones in general anaesthesia in rats.
Br. J. Anaesth. 107(6) , 924-9, (2011) Central noradrenergic neurones have a role in alertness, analgesia, and thermoregulation; these neurones are also involved in the mechanism of anaesthesia. Locus coeruleus neurones innervate various central nervous regions including the cerebral cortex and hi... |
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Noradrenergic neuromodulation in the olfactory bulb modulates odor habituation and spontaneous discrimination.
Behav. Neurosci. 122(4) , 816-26, (2008) Noradrenergic projections from the locus coeruleus (LC) project to the olfactory bulb (OB), a cortical structure implicated in odor learning and perceptual differentiation among similar odorants. The authors tested the role of OB noradrenaline (NA) in short-t... |