CGP 37157
CGP 37157 structure
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Common Name | CGP 37157 | ||
|---|---|---|---|---|
| CAS Number | 75450-34-9 | Molecular Weight | 324.225 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 479.8±45.0 °C at 760 mmHg | |
| Molecular Formula | C15H11Cl2NOS | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 244.0±28.7 °C | |
| Symbol |
GHS07, GHS09 |
Signal Word | Warning | |
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Pulsed infrared radiation excites cultured neonatal spiral and vestibular ganglion neurons by modulating mitochondrial calcium cycling.
J. Neurophysiol. 112(6) , 1246-55, (2014) Cochlear implants are currently the most effective solution for profound sensorineural hearing loss, and vestibular prostheses are under development to treat bilateral vestibulopathies. Electrical current spread in these neuroprostheses limits channel indepen... |
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UCP2 modulates single-channel properties of a MCU-dependent Ca(2+) inward current in mitochondria.
Pflugers Arch. 467 , 2509-18, (2015) The mitochondrial Ca(2+) uniporter is a highly Ca(2+)-selective protein complex that consists of the pore-forming mitochondrial Ca(2+) uniporter protein (MCU), the scaffolding essential MCU regulator (EMRE), and mitochondrial calcium uptake 1 and 2 (MICU1/2),... |
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Mitochondrial Ca(2+) uniporter (MCU)-dependent and MCU-independent Ca(2+) channels coexist in the inner mitochondrial membrane.
Pflugers Arch. 466(7) , 1411-20, (2014) A protein referred to as CCDC109A and then renamed to mitochondrial calcium uniporter (MCU) has recently been shown to accomplish mitochondrial Ca(2+) uptake in different cell types. In this study, we investigated whole-mitoplast inward cation currents and si... |
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CGP-37157 inhibits the sarcoplasmic reticulum Ca²+ ATPase and activates ryanodine receptor channels in striated muscle.
Mol. Pharmacol. 79 , 141-147, (2011) 7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepin-2(3H)-one [CGP-37157 (CGP)], a benzothiazepine derivative of clonazepam, is commonly used as a blocker of the mitochondrial Na+/Ca²+ exchanger. However, evidence suggests that CGP could also affect ot... |
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Depolarization-induced calcium responses in sympathetic neurons: relative contributions from Ca2+ entry, extrusion, ER/mitochondrial Ca2+ uptake and release, and Ca2+ buffering.
J. Gen. Physiol. 129 , 29-56, (2006) Many models have been developed to account for stimulus-evoked [Ca(2+)] responses, but few address how responses elicited in specific cell types are defined by the Ca(2+) transport and buffering systems that operate in the same cells. In this study, we extend... |
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Dissection of mitochondrial Ca2+ uptake and release fluxes in situ after depolarization-evoked [Ca2+](i) elevations in sympathetic neurons.
J. Gen. Physiol. 115 , 351-70, (2000) We studied how mitochondrial Ca2+ transport influences [Ca2+](i) dynamics in sympathetic neurons. Cells were treated with thapsigargin to inhibit Ca2+ accumulation by SERCA pumps and depolarized to elevate [Ca2+(i); the recovery that followed repolarization w... |