Calcitonin Gene Related Peptide Fragment 8-37 human

Calcitonin Gene Related Peptide Fragment 8-37 human Structure
Calcitonin Gene Related Peptide Fragment 8-37 human structure
Common Name Calcitonin Gene Related Peptide Fragment 8-37 human
CAS Number 119911-68-1 Molecular Weight 3125.59000
Density 1.46±0.1 g/cm3 Boiling Point N/A
Molecular Formula C139H230N44O38 Melting Point N/A
MSDS USA Flash Point N/A

Calcitonin gene-related peptide stimulates proliferation and osteogenic differentiation of osteoporotic rat-derived bone mesenchymal stem cells.

Mol. Cell Biochem. 402(1-2) , 101-10, (2015)

Osteoporosis, a systemic bone disorder, is prevalent in postmenopausal woman. Bone mesenchymal stem cells (BMSCs), precursors of osteogenic cells, may contribute to prevention or treatment of bone frustrate in osteoporosis. Recently, two studies suggested a r...

Intermedin enhances sympathetic outflow via receptor-mediated cAMP/PKA signaling pathway in nucleus tractus solitarii of rats.

Peptides 47 , 1-6, (2013)

Direct administration of intermedin (IMD) into the brain elicits cardiovascular effects different from the systemic administration. Nucleus tractus solitarii (NTS) is an important region for the cardiovascular regulation. The present study was designed to det...

Intermedin in paraventricular nucleus attenuates sympathetic activity and blood pressure via nitric oxide in hypertensive rats.

Hypertension 63(2) , 330-7, (2014)

Intermedin (IMD) is a member of calcitonin/calcitonin gene-related peptide family, which shares the receptor system consisting of calcitonin receptor-like receptor (CRLR) and receptor activity-modifying proteins (RAMPs). This study investigated the effects of...

Pain-like behaviour and spinal changes in the monosodium iodoacetate model of osteoarthritis in C57Bl/6 mice.

Eur. J. Pain 17(4) , 514-26, (2013)

Osteoarthritis (OA) is a highly prevalent, age-related pain condition that poses a significant clinical problem. Here, in the monosodium iodoacetate (MIA) model of OA, we have characterized pain behaviours and associated changes at the first pain synapse in t...

Substance P and calcitonin gene related peptide mediate pain in chronic pancreatitis and their expression is driven by nerve growth factor.

JOP 12(4) , 389-94, (2011)

Calcitonin gene-related peptide (CGRP), substance P and nerve growth factor play an important role in inflammatory pain in various somatic pain models but their role in chronic pancreatitis has not been well studied.The aim of this study was to investigate th...

Adrenomedullin enhances the progressive motility and zona pellucida-binding capacity of spermatozoa from normozoospermic but not asthenozoospermic men.

Mol. Reprod. Dev. 79(2) , 76, (2012)

Calcitonin gene-related peptide regulates the early phase of liver regeneration.

J. Surg. Res. 183(1) , 138-45, (2013)

To investigate the expression of calcitonin gene-related peptide (CGRP) and its role in the liver regeneration process after 70% hepatectomy (Hx).Wistar rats were divided into eight groups based on time after Hx. Remnant liver samples were collected serially ...

Inhibitory effect of calcitonin gene-related peptide on hypoxia-induced rat pulmonary artery smooth muscle cells proliferation: role of ERK1/2 and p27.

Eur. J. Pharmacol. 679(1-3) , 117-26, (2012)

Calcitonin gene-related peptide (CGRP) inhibits angiotensin II-induced proliferation of aortic smooth muscle cells via inactivation of extracellular signal-regulated protein kinase 1/2 (ERK1/2). ERK1/2 is necessary for the degradation or down-regulation of th...

Adrenomedullin in rat follicles and corpora lutea: expression, functions and interaction with endothelin-1.

Reprod. Biol. Endocrinol. 9 , 111, (2011)

Adrenomedullin (ADM), a novel vasorelaxant peptide, was found in human/rat ovaries. The present study investigated the interaction of ADM and endothelin-1 (ET-1) in follicles and newly formed corpora lutea (CL) and the actions of ADM on progesterone productio...

Role of calcitonin gene-related peptide in bone repair after cyclic fatigue loading.

PLoS ONE 6(6) , e20386, (2011)

Calcitonin gene related peptide (CGRP) is a neuropeptide that is abundant in the sensory neurons which innervate bone. The effects of CGRP on isolated bone cells have been widely studied, and CGRP is currently considered to be an osteoanabolic peptide that ha...