Calcitonin Gene Related Peptide Fragment 8-37 human

Modify Date: 2025-08-21 21:26:26

Calcitonin Gene Related Peptide Fragment 8-37 human structure	Common Name	Calcitonin Gene Related Peptide Fragment 8-37 human
	CAS Number	119911-68-1	Molecular Weight	3125.59000
	Density	1.46±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₁₃₉H₂₃₀N₄₄O₃₈	Melting Point	N/A
	MSDS	USA	Flash Point	N/A

Use of Calcitonin Gene Related Peptide Fragment 8-37 human

HCGRP-(8-37) is a human calcitonin gene-related peptide (hCGRP) fragment and also an antagonist of CGRP receptor. Sequence: Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asn-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Lys-Ala-Phe.

Name	CGRP 8-37 (human)
Synonym	More Synonyms

Description	HCGRP-(8-37) is a human calcitonin gene-related peptide (hCGRP) fragment and also an antagonist of CGRP receptor. Sequence: Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asn-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Lys-Ala-Phe.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> CGRP Receptor Signaling Pathways >> Neuronal Signaling >> CGRP Receptor Peptides Research Areas >> Cardiovascular Disease Research Areas >> Metabolic Disease
Target	CGRP receptor[1]
References	[1]. Chiba T, et al. Calcitonin gene-related peptide receptor antagonist human CGRP-(8-37). Am J Physiol. 1989 Feb;256(2 Pt 1):E331-5.

Density	1.46±0.1 g/cm3
Molecular Formula	C₁₃₉H₂₃₀N₄₄O₃₈
Molecular Weight	3125.59000
Exact Mass	3123.74000
PSA	1339.16000
LogP	1.11560
Appearance of Characters	powder
Storage condition	−20°C

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
RIDADR	NONH for all modes of transport
WGK Germany	3

Calcitonin gene-related peptide stimulates proliferation and osteogenic differentiation of osteoporotic rat-derived bone mesenchymal stem cells.

Mol. Cell Biochem. 402(1-2) , 101-10, (2015)

Osteoporosis, a systemic bone disorder, is prevalent in postmenopausal woman. Bone mesenchymal stem cells (BMSCs), precursors of osteogenic cells, may contribute to prevention or treatment of bone fru...

Intermedin enhances sympathetic outflow via receptor-mediated cAMP/PKA signaling pathway in nucleus tractus solitarii of rats.

Peptides 47 , 1-6, (2013)

Direct administration of intermedin (IMD) into the brain elicits cardiovascular effects different from the systemic administration. Nucleus tractus solitarii (NTS) is an important region for the cardi...

Intermedin in paraventricular nucleus attenuates sympathetic activity and blood pressure via nitric oxide in hypertensive rats.

Hypertension 63(2) , 330-7, (2014)

Intermedin (IMD) is a member of calcitonin/calcitonin gene-related peptide family, which shares the receptor system consisting of calcitonin receptor-like receptor (CRLR) and receptor activity-modifyi...

FBHuman

CGRP-I 8-37

EINECS 232-693-2

CGRP-I 8-37,HUMAN

MFCD00133153

VAL-THR-HIS-ARG-LEU-ALA-GLY-LEU-LEU-SER-ARG-SER-GLY-GLY-VAL-VAL-LYS-ASN-ASN-PHE-VAL-PRO-THR-ASN-VAL-GLY-SER-LYS-ALA-PHE-NH2

ALA-CYS-ASN-THR-ALA-THR-CYS-VAL-THR-HIS-ARG-LEU-ALA-ASP-PHE-LEU-SER-ARG-SER-GLY-GLY-VAL-GLY-LYS-ASN-ASN-PHE-VAL-PRO-THR-ASN-VAL-GLY-SER-LYS-ALA-PHE-NH2: ACNTATCVTHRLADFLSRSGGVGKNNFVPTNVGSKAF-NH2DISULFIDE BRIDGE

CYS2-CYS7

HCGRP-(8-37)