pimozide
pimozide structure
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Common Name | pimozide | ||
|---|---|---|---|---|
| CAS Number | 2062-78-4 | Molecular Weight | 461.546 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 649.0±65.0 °C at 760 mmHg | |
| Molecular Formula | C28H29F2N3O | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 346.3±34.3 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Simple and sensitive screening and quantitative determination of 88 psychoactive drugs and their metabolites in blood through LC–MS/MS: Application on postmortem samples
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 970 , 1-7, (2014) • The introduction has been modified. • More references have been added to the text. • Limitations of the method have been discussed more in detail. |
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Factors influencing crystal growth rates from undercooled liquids of pharmaceutical compounds.
J. Phys. Chem. B 118(33) , 9974-82, (2014) Amorphous forms of drugs are increasingly being used to deliver poorly water-soluble compounds. Therefore, understanding the magnitude and origin of differences in crystallization kinetics is highly important. The goal of this study was to better understand t... |
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Progesterone downregulation of miR-141 contributes to expansion of stem-like breast cancer cells through maintenance of progesterone receptor and Stat5a.
Oncogene 34 , 3676-87, (2015) Progesterone (P4) has emerged as an important hormone-regulating mammary stem cell (MaSC) populations. In breast cancer, P4 and synthetic analogs increase the number of stem-like cells within luminal estrogen receptor (ER)- and progesterone receptor (PR)-posi... |
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Structure-Based Screen Identifies a Potent Small Molecule Inhibitor of Stat5a/b with Therapeutic Potential for Prostate Cancer and Chronic Myeloid Leukemia.
Mol. Cancer Ther. 14 , 1777-93, (2015) Bypassing tyrosine kinases responsible for Stat5a/b phosphorylation would be advantageous for therapy development for Stat5a/b-regulated cancers. Here, we sought to identify small molecule inhibitors of Stat5a/b for lead optimization and therapy development f... |
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A human ether-á-go-go-related (hERG) ion channel atomistic model generated by long supercomputer molecular dynamics simulations and its use in predicting drug cardiotoxicity
Toxicol. Lett. 230(3) , 382-92, (2014) • Current hERG assays remain insensitive as predictors of clinical toxicity. • We have developed a state-of-art computational model of hERG blocking. • The method was validated using two biological assays of functional hERG blocking. • As an example the anti-... |
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Efficacy of Helicobacter pylori eradication for the 1st line treatment of immune thrombocytopenia patients with moderate thrombocytopenia.
Ann. Hematol. 94(5) , 739-46, (2015) The practical usefulness of Helicobacter pylori eradication for immune thrombocytopenia (ITP) patients is still controversial. However, some ITP patients respond to H. pylori eradication. We conducted a multi-center, open label, prospective phase II study to ... |
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Adrenal fasciculata cells express T-type and rapidly and slowly activating L-type Ca2+ channels that regulate cortisol secretion.
Am. J. Physiol. Cell Physiol. 308 , C899-918, (2015) In whole cell patch-clamp recordings, we characterized the L-type Ca(2+) currents in bovine adrenal zona fasciculata (AZF) cells and explored their role, along with the role of T-type channels, in ACTH- and angiotensin II (ANG II)-stimulated cortisol secretio... |
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Screening of DUB activity and specificity by MALDI-TOF mass spectrometry.
Nat. Commun. 5 , 4763, (2014) Deubiquitylases (DUBs) are key regulators of the ubiquitin system which cleave ubiquitin moieties from proteins and polyubiquitin chains. Several DUBs have been implicated in various diseases and are attractive drug targets. We have developed a sensitive and ... |
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Signal transducer and activator of transcription 5a inhibited by pimozide may regulate survival of goat mammary gland epithelial cells by regulating parathyroid hormone-related protein.
Gene 551(2) , 279-89, (2014) The signal transducer and activator of transcription 5a (Stat5a) modulates genes involved in proliferation and survival and plays pivotal roles in regulating the function of the mammary gland during pregnancy, lactation, and involution. However, there is litt... |
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Activity Profile of an FDA-Approved Compound Library against Schistosoma mansoni.
PLoS Negl. Trop. Dis. 9 , e0003962, (2015) As plans to expand mass drug treatment campaigns to fight schistosomiasis form, worries about reliance on praziquantel as the sole available treatment motivate the investigation for novel antischistosomal compounds. Drug repurposing might be an inexpensive an... |