GR 79236
GR 79236 structure
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Common Name | GR 79236 | ||
|---|---|---|---|---|
| CAS Number | 124555-18-6 | Molecular Weight | 351.35800 | |
| Density | 1.89g/cm3 | Boiling Point | 728.3ºC at 760mmHg | |
| Molecular Formula | C15H21N5O5 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 394.3ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Multicentre evaluation of the adenosine agonist GR79236X in patients with dental pain after third molar extraction.
Br. J. Anaesth. 98(5) , 672-6, (2007) Adenosine is analgesic in humans, and the selective adenosine A1 receptor agonist GR79236X has significant anti-nociceptive activity in an animal pain model of inflammatory pain.Seventy-nine patients with moderate pain after third molar extraction under gener... |
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Does a selective adenosine A(1) receptor agonist protect against exercise induced ischaemia in patients with coronary artery disease?
Heart 87(2) , 115-20, (2002) The "warm up" effect in angina may represent ischaemic preconditioning, which is mediated by adenosine A(1) receptors in most models.To investigate the effect of a selective A(1) agonist, GR79236 (GlaxoSmithKline), on exercise induced angina and ischaemic lef... |
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Improvement of ketoacidosis in the diabetic rat after the administration of the oral antilipolytic agent GR 79236.
Clin. Sci. 86(5) , 593-8, (1994) 1. We assessed the effect of a novel oral antilipolytic agent, N-[(1S, trans)-2-hydroxycyclopentyl]adenosine (GR 79236), in experimental diabetic ketoacidosis. Ketotic rats were gavaged with GR 79236 (1 mg/kg) or water (vehicle) and their blood/plasma/serum b... |
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The effects of GR79236 on plasma fatty acid concentrations, heart rate and blood pressure in the conscious rat.
Eur. J. Pharmacol. 257(1-2) , 117-21, (1994) GR79236 (N-[(1S,trans)-2-hydroxycyclopentyl]adenosine) is an orally active adenosine A1 receptor agonist, which decreases plasma non-esterified fatty acid levels in fasted rats. This study has quantified the effects of GR79236 on plasma non-esterified fatty a... |
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Calcitonin gene-related peptide and substance P regulate the intestinal radiation response.
Clin. Cancer Res. 12(13) , 4112-8, (2006) Intestinal toxicity is important in the therapeutic use of radiation as well as in nontherapeutic radiation exposure scenarios. Enteric sensory nerves are critical for mucosal homeostasis and for an appropriate response to injury. This study assessed the role... |
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In vitro effect of adenosine agonist GR79236 on the insulin sensitivity of glucose utilisation in rat soleus and human rectus abdominus muscle.
Biochim. Biophys. Acta 1316(2) , 109-13, (1996) The dose-response effects of a new adenosine agonist, GR79236, were examined in isolated rat soleus muscle strips and human rectus abdominus muscle strips. Effects on the insulin sensitivity of carbohydrate metabolism were examined, in particular upon insulin... |
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Study of an adenosine A1 receptor agonist on trigeminally evoked dural blood vessel dilation in the anaesthetized rat.
Cephalalgia 22(4) , 260-4, (2002) The purpose of this study was to use intravital microscopy to determine the effect of a selective adenosine A1 receptor agonist, GR79236 (1, 3 and 10 microg/kg i.v.), on neurogenic dural blood vessel dilation in anaesthetized rats. Vasodilation was evoked eit... |
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Cardiovascular and antilipolytic effects of the adenosine agonist GR79236.
Pharmacology 51(4) , 224-36, (1995) Adenosine is known to produce cardiovascular effects such as bradycardia and hypotension via activation of myocardial (A1) and vascular (A2) receptors and antilipolytic effects through activation of adipocyte (A1) receptors. We established the cardiovascular ... |
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Adenosine A1 receptor agonist GR79236 suppresses apnea during all sleep stages in the rat.
Sleep 20(12) , 1093-8, (1997) We tested the hypothesis that N-[(1S, trans)-2-hydroxycyclopentyl]adenosine (GR79236), a novel adenosine A1 receptor agonist, would suppress sleep-related apnea in the rat at doses not associated with hypotension or hypothermia. Nine adult Sprague-Dawley rats... |
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Adenosine effects upon insulin action on lipolysis and glucose transport in human adipocytes.
Mol. Cell Biochem. 144(2) , 147-51, (1995) The dose response effect of a new adenosine analogue, GR79236 (N-[1S trans-2-hydroxycyclopentyl] adenosine) upon insulin sensitivity was examined in human adipocytes. The influence of adenosine upon insulin sensitivity for suppression of lipolysis and stimula... |