1-(4,4-diphenyl-3-butenyl)-3-piperidinecarboxylicacidhydrochloride；SKF89976AHCl
1-(4,4-diphenyl-3-butenyl)-3-piperidinecarboxylicacidhydrochloride；SKF89976AHCl structure
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Common Name | 1-(4,4-diphenyl-3-butenyl)-3-piperidinecarboxylicacidhydrochloride；SKF89976AHCl | ||
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| CAS Number | 85375-15-1 | Molecular Weight | 371.90000 | |
| Density | N/A | Boiling Point | 531.4ºC at 760 mmHg | |
| Molecular Formula | C22H26ClNO2 | Melting Point | N/A | |
| MSDS | USA | Flash Point | 275.2ºC | |
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Age-dependent changes in the susceptibility to thiopental anesthesia in mice: analysis of the relationship to the functional expression of GABA transporter.
Pharmacol. Biochem. Behav. 103(2) , 267-72, (2012) The potency of anesthetics changes during development, probably due not only to pharmacokinetic factors such as differential distribution and/or metabolism, but also to pharmacodynamic factors such as changes to the GABAergic system in the brain. To explore t... |
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Stiripentol, a putative antiepileptic drug, enhances the duration of opening of GABA-A receptor channels.
Epilepsia 47 , 706-716, (2006) Stiripentol (STP) is currently an efficient drug for add-on therapy in infantile epilepsies because it improves the efficacy of antiepileptic drugs (AEDs) through its potent inhibition of liver cytochromes P450. In addition, STP directly reduces seizures in s... |
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Selective gating of glutamatergic inputs to excitatory neurons of amygdala by presynaptic GABAb receptor.
Neuron 61(6) , 917-29, (2009) GABAb receptor (GABAbR)-mediated suppression of glutamate release is critical for limiting glutamatergic transmission across the central nervous system (CNS). Here we show that, upon tetanic stimulation of afferents to lateral amygdala, presynaptic GABAbR-med... |
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GABA transporter subtype 1 and GABA transporter subtype 3 modulate glutamatergic transmission via activation of presynaptic GABA(B) receptors in the rat globus pallidus.
Eur. J. Neurosci. 36(4) , 2482-92, (2012) The intra-pallidal application of γ-aminobutyric acid (GABA) transporter subtype 1 (GAT-1) or GABA transporter subtype 3 (GAT-3) transporter blockers [1-(4,4-diphenyl-3-butenyl)-3-piperidinecarboxylic acid hydrochloride (SKF 89976A) or 1-[2-[tris(4-methoxyphe... |
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Neurogliaform cells dynamically regulate somatosensory integration via synapse-specific modulation.
Nat. Neurosci. 16(1) , 13-5, (2013) Despite the prevailing idea that neurogliaform cells produce a spatially unrestricted widespread inhibition, we demonstrate here that their activity attenuates thalamic-evoked feed-forward inhibition in layer IV barrel cortex but has no effect on feed-forward... |
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Electrically evoked GABA release in rat hippocampus CA1 region and its changes during kindling epileptogenesis.
Brain Res. 1135(1) , 69-76, (2007) Previous findings on changes in K+-induced GABA release from hippocampal slices during kindling epileptogenesis were reinvestigated using physiological electrical stimulation. For that purpose, a procedure was developed enabling neurochemical monitoring of GA... |
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Postdepolarization potentiation of GABAA receptors: a novel mechanism regulating tonic conductance in hippocampal neurons.
J. Neurosci. 30(22) , 7672-84, (2010) Ambient GABA in the brain activates GABA(A) receptors to produce tonic inhibition. Membrane potential influences both GABA transport and GABA(A) receptors and could thereby regulate tonic inhibition. We investigated the voltage dependence of tonic currents in... |
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Interneurone bursts are spontaneously associated with muscle contractions only during early phases of mouse spinal network development: a study in organotypic cultures.
Eur. J. Neurosci. 20(10) , 2697-710, (2004) For a short time during development immature circuits in the spinal cord and other parts of the central nervous system spontaneously generate synchronous patterns of rhythmic activity. In the case of the spinal cord, it is still unclear how strongly synchroni... |
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In vitro activation of GAT1 transporters expressed in spinal cord gliosomes stimulates glutamate release that is abnormally elevated in the SOD1/G93A(+) mouse model of amyotrophic lateral sclerosis.
J. Neurochem. 113(2) , 489-501, (2010) The effect of GABA on glutamate release from astrocytes has been studied in healthy mice and in a murine transgenic model of amyotrophic lateral sclerosis (ALS), using mouse spinal cord gliosomes labeled with [(3)H]d-aspartate ([(3)H]d-ASP). GABA concentratio... |
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Passive water permeability of some wild type and mutagenized amino acid cotransporters of the SLC6/NSS family expressed in Xenopus laevis oocytes.
Comp. Biochem. Physiol. A. Mol. Integr. Physiol. 156(4) , 509-17, (2010) In this paper passive water movement across the cell membrane mediated by wild type and mutagenized cotransporters was investigated. We evaluated water movement and, in parallel, amino acid uptake induced by some members of the SLC6/NSS family belonging to di... |