Nature Neuroscience 2013-01-01

Neurogliaform cells dynamically regulate somatosensory integration via synapse-specific modulation.

Ramesh Chittajallu, Kenneth A Pelkey, Chris J McBain

Index: Nat. Neurosci. 16(1) , 13-5, (2013)

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Abstract

Despite the prevailing idea that neurogliaform cells produce a spatially unrestricted widespread inhibition, we demonstrate here that their activity attenuates thalamic-evoked feed-forward inhibition in layer IV barrel cortex but has no effect on feed-forward excitation. The result of this circuit selectivity is a dynamic regulation in the temporal window for integration of excitatory thalamic input, thus revealing a new role for neurogliaform cells in shaping sensory processing.