1-Ethyl-1,3-dihydro-2H-benzimidazol-2-one
1-Ethyl-1,3-dihydro-2H-benzimidazol-2-one structure
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Common Name | 1-Ethyl-1,3-dihydro-2H-benzimidazol-2-one | ||
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| CAS Number | 10045-45-1 | Molecular Weight | 162.189 | |
| Density | 1.161±0.06 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C9H10N2O | Melting Point | 122 ºC | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Differentiation between human ClC-2 and CFTR Cl- channels with pharmacological agents.
Am. J. Physiol. Cell Physiol. 307(5) , C479-92, (2014) It has been difficult to separate/identify the roles of ClC-2 and CFTR in Cl(-) transport studies. Using pharmacological agents, we aimed to differentiate functionally between ClC-2 and CFTR Cl(-) channel currents. Effects of CFTR inhibitor 172 (CFTRinh172), ... |
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Type 2 diabetes: increased expression and contribution of IKCa channels to vasodilation in small mesenteric arteries of ZDF rats.
Am. J. Physiol. Heart Circ. Physiol. 307(8) , H1093-102, (2014) Impaired endothelial function, which is dysregulated in diabetes, also precedes hypertension. We hypothesized that in Type 2 diabetes, the impaired endothelium-dependent relaxation is due to a loss of endothelium-derived hyperpolarization (EDH) that is regula... |
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Firing pattern modulation through SK channel current increase underlies neuronal survival in an organotypic slice model of Parkinson's disease.
Mol. Neurobiol. 51(1) , 424-36, (2015) Dopaminergic (DA) neurons in substantia nigra pars compacta (SNc) are vulnerable to excitotoxicity in Parkinson's disease (PD). Neurotoxic stimuli may alter the firing patterns of DA neurons. However, whether firing pattern change underlies neurotoxic stress-... |
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Increased Basolateral Amygdala Pyramidal Cell Excitability May Contribute to the Anxiogenic Phenotype Induced by Chronic Early-Life Stress.
J. Neurosci. 35 , 9730-40, (2015) Adolescence represents a particularly vulnerable period during which exposure to stressors can precipitate the onset of psychiatric disorders and addiction. The basolateral amygdala (BLA) plays an integral role in the pathophysiology of anxiety and addiction.... |
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Identification of the functional binding pocket for compounds targeting small-conductance Ca²⁺-activated potassium channels.
Nat. Commun. 3 , 1021, (2012) Small- and intermediate-conductance Ca(2+)-activated potassium channels, activated by Ca(2+)-bound calmodulin, have an important role in regulating membrane excitability. These channels are also linked to clinical abnormalities. A tremendous amount of effort ... |
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SK2 channels are neuroprotective for ischemia-induced neuronal cell death.
J. Cereb. Blood Flow Metab. 31(12) , 2302-12, (2011) In mouse hippocampal CA1 pyramidal neurons, the activity of synaptic small-conductance Ca(2+)-activated K(+) channels type 2 (SK2 channels) provides a negative feedback on N-methyl-D-aspartate receptors (NMDARs), reestablishing Mg(2+) block that reduces Ca(2+... |
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Small conductance calcium-activated potassium type 2 channels regulate alcohol-associated plasticity of glutamatergic synapses.
Biol. Psychiatry 69(7) , 625-32, (2011) Small conductance calcium-activated potassium type 2 channels (SK2) control excitability and contribute to plasticity by reducing excitatory postsynaptic potentials. Recent evidence suggests that SK2 channels form a calcium-dependent negative-feedback loop wi... |
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An SK3 channel/nWASP/Abi-1 complex is involved in early neurogenesis.
PLoS ONE 6(3) , e18148, (2011) The stabilization or regulated reorganization of the actin cytoskeleton is essential for cellular structure and function. Recently, we could show that the activation of the SK3-channel that represents the predominant SK-channel in neural stem cells, leads to ... |
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Mechanisms of bicarbonate secretion: lessons from the airways.
Cold Spring Harb. Perspect. Med. 2(8) , doi:10.1101/cshperspect.a015016, (2012) Early studies showed that airway cells secrete HCO(3)(-) in response to cAMP-mediated agonists and HCO(3)(-) secretion was impaired in cystic fibrosis (CF). Studies with Calu-3 cells, an airway serous model with high expression of CFTR, also show the secretio... |
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In vivo pharmacological manipulation of small conductance Ca(2+)-activated K(+) channels influences motor behavior, object memory and fear conditioning.
Neuropharmacology 58(3) , 650-9, (2010) Small conductance Ca(2+)-activated K(+) channels (SK, K(Ca2.1), K(Ca2.2), K(Ca2.3)) are expressed at high levels in brain regions critical for learning and memory. The activation of dendritic SK channels limits the induction of synaptic plasticity that may un... |