KT5720
KT5720 structure
|
Common Name | KT5720 | ||
|---|---|---|---|---|
| CAS Number | 108068-98-0 | Molecular Weight | 537.60600 | |
| Density | 1.49g/cm3 | Boiling Point | 715ºC at 760mmHg | |
| Molecular Formula | C32H31N3O5 | Melting Point | N/A | |
| MSDS | USA | Flash Point | 386.2ºC | |
|
Pro-migratory actions of the prostacyclin receptor in human breast cancer cells that over-express cyclooxygenase-2.
Biochem. Pharmacol. 96 , 306-14, (2015) Metastasis is the major cause of death in cancer patients. Elevated expression of cyclooxygenase-2 (COX-2) is observed in many human cancers and over-production of downstream prostaglandins (PGs) has been shown to stimulate metastasis. A role for increased PG... |
|
|
Involvement of cAMP in nerve growth factor-triggered p35/Cdk5 activation and differentiation in PC12 cells.
Am. J. Physiol. Cell Physiol. 299 , C516-27, (2010) The signaling mechanisms underlying cell differentiation have been extensively studied with the use of rat PC12 cells as a model system. Nerve growth factor (NGF) is a trophic factor inducing PC12 cell differentiation through the activation of the p35/cyclin-... |
|
|
Prostaglandin potentiates 5-HT responses in stomach and ileum innervating visceral afferent sensory neurons.
Biochem. Biophys. Res. Commun. 456(1) , 167-72, (2015) Gastrointestinal disorder is a common symptom induced by diverse pathophysiological conditions that include food tolerance, chemotherapy, and irradiation for therapy. Prostaglandin E2 (PGE2) level increase was often reported during gastrointestinal disorder a... |
|
|
Dopamine D1 receptors regulate type 1 inositol 1,4,5-trisphosphate receptor expression via both AP-1- and NFATc4-mediated transcriptional processes.
J. Neurochem. 122(4) , 702-13, (2012) Although our recent report demonstrates the essential involvement of up-regulation of a regulator of intracellular Ca(2+) concentration, type 1 inositol 1,4,5-trisphosphate receptors (IP(3) Rs-1), mediated via dopamine D1-like receptor (D1DR) stimulation in t... |
|
|
Cyclooxygenase-2 up-regulates vascular endothelial growth factor via a protein kinase C pathway in non-small cell lung cancer.
J. Exp. Clin. Cancer Res 30 , 6, (2011) Vascular endothelial growth factor (VEGF) expression is up-regulated via a cyclooxygenase-2 (COX-2)-dependent mechanism in non-small cell lung cancer (NSCLC), but the specific signaling pathway involved is unclear. Our aim was to investigate the signaling pat... |
|
|
Idebenone inhibition of glutamate release from rat cerebral cortex nerve endings by suppression of voltage-dependent calcium influx and protein kinase A.
Naunyn Schmiedebergs Arch. Pharmacol. 384(1) , 59-70, (2011) The present study was aimed at investigating the effect and the possible mechanism of idebenone on endogenous glutamate release in nerve terminals of rat cerebral cortex (synaptosomes). Idebenone inhibited the release of glutamate that was evoked by exposing ... |
|
|
Cyclooxygenase-2 up-regulates CCR7 via EP2/EP4 receptor signaling pathways to enhance lymphatic invasion of breast cancer cells.
J. Biol. Chem. , 11155-63, (1999) Recent studies demonstrate that cyclooxygenase-2 (COX-2) expression is frequently associated with lymph node metastasis. However, the mechanism by which COX-2 increases the invasion of cancer cells to lymph node is unclear. CCR7 is a chemokine receptor that p... |
|
|
Angiotensin II type 2 receptor agonist directly inhibits proximal tubule sodium pump activity in obese but not in lean Zucker rats.
Hypertension , 1117-24, (2008) We have reported recently that the renal angiotensin II type 2 (AT2) receptors are upregulated and involved in promoting natriuresis/diuresis in obese but not in lean Zucker rats. In the present study, we tested the hypothesis that there is an enhanced AT2 re... |
|
|
14-3-3 Proteins Regulate a Cell-Intrinsic Switch from Sonic Hedgehog-Mediated Commissural Axon Attraction to Repulsion after Midline Crossing
Neuron 76(4) , 735-49, (2012) Axons must switch responsiveness to guidance cues during development for correct pathfinding. Sonic Hedgehog (Shh) attracts spinal cord commissural axons ventrally toward the floorplate. We show that after crossing the floorplate, commissural axons switch the... |
|
|
Critical role for protein kinase A in the acquisition of gregarious behavior in the desert locust.
Proc. Natl. Acad. Sci. U. S. A. 109(7) , E381-7, (2012) The mechanisms that integrate genetic and environmental information to coordinate the expression of complex phenotypes are little understood. We investigated the role of two protein kinases (PKs) in the population density-dependent transition to gregarious be... |