S(+)-Niguldipine hydrochloride
S(+)-Niguldipine hydrochloride structure
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Common Name | S(+)-Niguldipine hydrochloride | ||
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| CAS Number | 113165-32-5 | Molecular Weight | 609.71100 | |
| Density | 1.205g/cm3 | Boiling Point | 729.5ºC at 760 mmHg | |
| Molecular Formula | C36H39N3O6 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 395ºC | |
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(+)-Niguldipine binds with very high affinity to Ca2+ channels and to a subtype of alpha 1-adrenoceptors.
Eur. J. Pharmacol. 172 , 131-145, (1989) The enantiomers of the 1,4-dihydropyridine (DHP) niguldipine (3-methyl-5-[3-(4,4-diphenyl-1-piperidinyl)-propyl]- 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-pyridine-3,5-dicarboxylate- hydrochloride) were investigated with respect to their interaction with 1,... |
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Pharmacological modulation of calcium and potassium channels in isolated vascular smooth muscle cells.
Arzneimittelforschung 39 , 120-126, (1989) Calcium antagonists relax vascular smooth muscle cells (VSM) by decreasing Ca-influx and intracellular Ca-load. In isolated VSM, Ca-influx was measured as Ca-current by the voltage clamp technique applied to a patch of membrane (single-channel current) or to ... |
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