S(+)-Niguldipine hydrochloride
Modify Date: 2025-08-25 13:35:20
S(+)-Niguldipine hydrochloride structure
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Common Name | S(+)-Niguldipine hydrochloride | ||
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| CAS Number | 113165-32-5 | Molecular Weight | 609.71100 | |
| Density | 1.205g/cm3 | Boiling Point | 729.5ºC at 760 mmHg | |
| Molecular Formula | C36H39N3O6 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 395ºC | |
| Name | S(+)-Niguldipine hydrochloride |
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| Synonym | More Synonyms |
| Density | 1.205g/cm3 |
|---|---|
| Boiling Point | 729.5ºC at 760 mmHg |
| Molecular Formula | C36H39N3O6 |
| Molecular Weight | 609.71100 |
| Flash Point | 395ºC |
| Exact Mass | 609.28400 |
| PSA | 113.69000 |
| LogP | 6.80790 |
| Vapour Pressure | 3.9E-21mmHg at 25°C |
| Index of Refraction | 1.589 |
| InChIKey | SVJMLYUFVDMUHP-XIFFEERXSA-N |
| SMILES | COC(=O)C1=C(C)NC(C)=C(C(=O)OCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1cccc([N+](=O)[O-])c1 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
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(+)-Niguldipine binds with very high affinity to Ca2+ channels and to a subtype of alpha 1-adrenoceptors.
Eur. J. Pharmacol. 172 , 131-145, (1989) The enantiomers of the 1,4-dihydropyridine (DHP) niguldipine (3-methyl-5-[3-(4,4-diphenyl-1-piperidinyl)-propyl]- 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-pyridine-3,5-dicarboxylate- hydrochloride) ... |
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Pharmacological modulation of calcium and potassium channels in isolated vascular smooth muscle cells.
Arzneimittelforschung 39 , 120-126, (1989) Calcium antagonists relax vascular smooth muscle cells (VSM) by decreasing Ca-influx and intracellular Ca-load. In isolated VSM, Ca-influx was measured as Ca-current by the voltage clamp technique app... |
| MFCD00873564 |
| (S)-(+)-Niguldipine hydrochloride,(S)-1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylicacid,3-(4,4-diphenyl-1-piperidinyl)propylmethylesterhydrochloride |