SC-560
SC-560 structure
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Common Name | SC-560 | ||
|---|---|---|---|---|
| CAS Number | 188817-13-2 | Molecular Weight | 352.738 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 440.6±45.0 °C at 760 mmHg | |
| Molecular Formula | C17H12ClF3N2O | Melting Point | 63 °C | |
| MSDS | Chinese USA | Flash Point | 220.3±28.7 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Arachidonic acid downregulates acyl-CoA synthetase 4 expression by promoting its ubiquitination and proteasomal degradation.
J. Lipid Res. 55(8) , 1657-1667, (2014) ACSL4 is a member of the long-chain acyl-CoA synthetase (ACSL) family with a marked preference for arachidonic acid (AA) as its substrate. Although an association between elevated levels of ACSL4 and hepatosteatosis has been reported, the function of ACSL4 in... |
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Mechanisms for proteinase-activated receptor 1-triggered prostaglandin E2 generation in mouse osteoblastic MC3T3-E1 cells.
Biol. Chem. 396(2) , 153-62, (2015) We analyzed signaling mechanisms for prostaglandin E2 (PGE2) production following activation of proteinase-activated receptor-1 (PAR1), a thrombin receptor, in preosteoblastic MC3T3-E1 cells. PAR1 stimulation caused PGE2 release, an effect suppressed by inhib... |
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COX-2 inhibition improves retinal function in rats' ischemic eyes.
J. Ocul. Pharmacol. Ther. 30(8) , 634-41, (2014) Retinal ischemia is a relatively simple model for studies in pharmacological neuroprotective intervention. The role of cyclooxygenase (COX) enzymes in ischemic insult has been variously shown to either increase or decrease ischemic damage. The purpose of this... |
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Effects of SC-560 in combination with cisplatin or taxol on angiogenesis in human ovarian cancer xenografts.
Int. J. Mol. Sci. 15(10) , 19265-80, (2014) This study was designed to evaluate the effect of cyclooxygenase-1 (COX-1) inhibitor, SC-560, combined with cisplatin or taxol, on angiogenesis in human ovarian cancer xenografts. Mice were treated with intraperitoneal (i.p.) injections of SC-560 6 mg/kg/day,... |
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Glutamate-mediated upregulation of the multidrug resistance protein 2 in porcine and human brain capillaries.
J. Pharmacol. Exp. Ther. 352(2) , 368-78, (2015) As a member of the multidrug-resistance associated protein (MRP) family, MRP2 affects the brain entry of different endogenous and exogenous compounds. Considering the role of this transporter at the blood-brain barrier, the regulation is of particular interes... |
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Accelerated fracture healing in mice lacking the 5-lipoxygenase gene.
Acta Orthop. 81 , 748-55, (2010) Cyclooxygenase-2 (COX-2) promotes inflammation by synthesizing pro-inflammatory prostaglandins from arachidonic acid. Inflammation is an early response to bone fracture, and ablation of COX-2 activity impairs fracture healing. Arachidonic acid is also convert... |
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Effect of cyclooxygenase inhibition on cholesterol efflux proteins and atheromatous foam cell transformation in THP-1 human macrophages: a possible mechanism for increased cardiovascular risk.
Arthritis. Res. Ther. 9 , R4, (2007) Both selective cyclooxygenase (COX)-2 inhibitors and non-steroidal anti-inflammatory drugs (NSAIDs) have been beneficial pharmacological agents for many patients suffering from arthritis pain and inflammation. However, selective COX-2 inhibitors and tradition... |
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Prostaglandin E2 stimulates Fas ligand expression via the EP1 receptor in colon cancer cells.
Br. J. Cancer 99 , 502-12, (2008) Fas ligand (FasL/CD95L) is a member of the tumour necrosis factor superfamily that triggers apoptosis following crosslinking of the Fas receptor. Despite studies strongly implicating tumour-expressed FasL as a major inhibitor of the anti-tumour immune respons... |