Oxotremorine sesquifumarate
Oxotremorine sesquifumarate structure
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Common Name | Oxotremorine sesquifumarate | ||
|---|---|---|---|---|
| CAS Number | 17360-35-9 | Molecular Weight | 760.78500 | |
| Density | N/A | Boiling Point | 373.9ºC at 760 mmHg | |
| Molecular Formula | C36H48N4O14 | Melting Point | 102-105ºC(lit.) | |
| MSDS | Chinese USA | Flash Point | 169.1ºC | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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Acetylcholine activity in selective striatal regions supports behavioral flexibility.
Neurobiol. Learn. Mem. 91(1) , 13-22, (2009) Daily living often requires individuals to flexibly respond to new circumstances. There is considerable evidence that the striatum is part of a larger neural network that supports flexible adaptations. Cholinergic interneurons are situated to strongly influen... |
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Stress-induced immobility in rats with cholinergic supersensitivity.
Biol. Psychiatry 21(7) , 657-64, (1986) Immobility during forced swimming or after mild footshock (1 mA for 2 sec) was observed in five groups of rats. The Flinders Sensitive Line (FSL) of rats, known to be more sensitive to cholinergic agonists, exhibited the greatest degree of immobility in the f... |
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Memory-modulatory effects of centrally acting noradrenergic drugs: possible involvement of brain cholinergic mechanisms.
Behav. Neural Biol 57(3) , 248-55, (1992) Post-training administration of the centrally acting muscarinic agonist oxotremorine (50.0 microgram/kg, ip) facilitated 48-hr retention, in mice, of a one-trial step-through inhibitory avoidance response. Oxotremorine-induced memory facilitation was not prev... |
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Acetylcholine via muscarinic receptors inhibits histamine release from human isolated bronchi.
Am. J. Respir. Crit. Care Med. 156(2 Pt 1) , 389-95, (1997) Human bronchi were incubated in organ baths to measure histamine release. The calcium ionophore A23187 (10 mumol/L; 1 min) stimulated histamine release by 148 +/- 28% (n = 11) above the prestimulation level but was ineffective in epithelium-denuded bronchi. N... |
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An in vivo pharmacological study on muscarinic receptor subtypes regulating cholinergic neurotransmission in rat striatum.
Biochem. Pharmacol. 36(18) , 3075-7, (1987)
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Retention enhancement by pre-test beta-endorphin and oxotremorine and its reversal by scopolamine.
Behav. Neural Biol 50(3) , 251-4, (1988) The pre-test administration of beta-endorphin (0.05 microgram/mouse), oxotremorine sesquifumarate (5.0 micrograms/mouse), or beta-endorphin plus oxotremorine enhanced retention test performance of a conditioned emotional response in mice. The effects were blo... |
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Nucleus accumbens acetylcholine and food intake: Decreased muscarinic tone reduces feeding but not food-seeking
Behav. Brain Res. 198(1) , 252-7, (2009) Separate groups of food-deprived rats were given 2 h access to food after receiving bilateral nucleus accumbens infusions of the muscarinic antagonist scopolamine methyl bromide (at 0, 1.0, and 10.0 μg/side), the M2-preferring agonist oxotremorine sesquifumar... |
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Cholinergic effects on fear conditioning II: nicotinic and muscarinic modulations of atropine-induced disruption of the degraded contingency effect.
Psychopharmacology 178(4) , 533-41, (2005) In a companion study (Carnicella et al., 2005), we showed that the muscarinic antagonist atropine, when administered after extensive training during both conditioning and testing, affected neither cued nor contextual fear memories when both of them did not co... |
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Muscarinic type 2 receptors in the lateral dorsal tegmental area modulate cocaine and food seeking behavior in rats.
Neuroscience 170(2) , 559-69, (2010) The cholinergic input from the lateral dorsal tegmental area (LDTg) modulates the dopamine cells of the ventral tegmental area (VTA) and plays an important role in cocaine taking. Specific pharmacological agents that block or stimulate muscarinic receptors in... |
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Pretest beta-endorphin and epinephrine, but not oxotremorine, reverse retrograde interference of a conditioned emotional response in mice.
Pharmacol. Biochem. Behav. 33(3) , 545-8, (1989) CD-1 mice were trained in a classically conditioned emotional response paradigm and tested 24 hr later. Exposure to an open field 0 or 1, but not 3 hr after training retroactively interfered with retention of the conditioned emotional response. The retroactiv... |