trans-Styrylacetic acid
trans-Styrylacetic acid structure
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Common Name | trans-Styrylacetic acid | ||
|---|---|---|---|---|
| CAS Number | 1914-58-5 | Molecular Weight | 162.18500 | |
| Density | 1.145 g/cm3 | Boiling Point | 302ºC at 760 mmHg | |
| Molecular Formula | C10H10O2 | Melting Point | 82-88ºC | |
| MSDS | Chinese USA | Flash Point | 215.8ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Synthesis and antimalarial and antituberculosis activities of a series of natural and unnatural 4-methoxy-6-styryl-pyran-2-ones, dihydro analogues and photo-dimers.
Bioorg. Med. Chem. 20 , 1482-93, (2012) Previous studies have identified the 3,6-dialkyl-4-hydroxy-pyran-2-one marine microbial metabolites pseudopyronines A and B to be modest growth inhibitors of Mycobacterium tuberculosis and a range of tropical diseases including Plasmodium falciparum and Leish... |
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4-Phenyl-3-butenoic acid, an in vivo inhibitor of peptidylglycine hydroxylase (peptide amidating enzyme).
Eur. J. Biochem. 189(2) , 363-8, (1990) The ability of a series of non-peptide carboxylic acids to act as substrates or inhibitors of the peptide-amidating enzyme (peptidyl-glycine hydroxylase) was assessed by determining their ability to reduce the rate of enzymic conversion of D-tyrosyl-valyl-gly... |
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Selective mechanism-based inactivation of peptidylglycine alpha-hydroxylating monooxygenase in serum and heart atrium vs. brain.
Biochem. Pharmacol. 53(11) , 1695-702, (1997) Peptidylglycine alpha-hydroxylating monooxygenase (PHM; EC 1.14.17.3) catalyses the rate-limiting step in the post-translational activation of substance P, among other neuropeptides, from its glycine-extended precursor. Comparative kinetic studies were perfor... |
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Fragrance material review on 4-phenyl-3-buten-2-ol.
Food Chem. Toxicol. 50 Suppl 2 , S120-3, (2012) A toxicologic and dermatologic review of 4-phenyl-3-buten-2-ol when used as a fragrance ingredient is presented. 4-Phenyl-3-buten-2-ol is a member of the fragrance structural group Aryl Alkyl Alcohols and is a secondary alcohol. The AAAs are a structurally di... |
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Probing the peptidylglycine alpha-hydroxylating monooxygenase active site with novel 4-phenyl-3-butenoic acid based inhibitors.
ChemMedChem 5(9) , 1568-76, (2010) Specific inhibition of the copper-containing peptidylglycine alpha-hydroxylating monooxygenase (PHM), which catalyzes the post-translational modification of peptides involved in carcinogenesis and tumor progression, constitutes a new approach for combating ca... |
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Reversal of the transformed phenotype and inhibition of peptidylglycine alpha-monooxygenase in Ras-transformed cells by 4-phenyl-3-butenoic acid.
Mol. Carcinog. 41(4) , 231-46, (2004) Recent studies have shown that the proliferation of some tumor cells is dependent on autocrine growth loops that require amidated autocrine growth factors. Peptidylglycine alpha-monooxygenase (PAM) is required for amidation of these growth factors and, theref... |
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Peptide amidating enzymes are present in cultured endothelial cells.
Biochem. Biophys. Res. Commun. 184(1) , 323-9, (1992) Carboxy-terminal amidation is a prevalent post-translational modification necessary for the bioactivity of many peptides. We now report that the two enzymes essential for amidation, peptidylglycine alpha-monooxygenase (PAM) and peptidylamidoglycolate lyase (P... |
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Peptidylglycine-alpha-hydroxylating monooxygenase generates two hydroxylated products from its mechanism-based suicide substrate, 4-phenyl-3-butenoic acid.
Biochemistry 39(27) , 8007-16, (2000) The bifunctional enzyme peptidylglycine-alpha-amidating monooxygenase mediates the conversion of C-terminal glycine-extended peptides to their active alpha-amidated products. Peptidylglycine-alpha-hydroxylating monooxygenase (PHM, EC 1.14.17. 3) catalyzes the... |
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Vascular and endothelial actions of inhibitors of substance P amidation.
J. Cardiovasc. Pharmacol. 35(6) , 871-80, (2000) Formation of mature active neuropeptides such as substance P (SP) from their glycine extended precursors entails alpha-amidation of peptide precursors by the sequential enzymatic action of peptidylglycine alpha-monooxygenase (PAM) and peptidylamidoglycolate l... |
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Streptomyces koyangensis sp. nov., a novel actinomycete that produces 4-phenyl-3-butenoic acid.
Int. J. Syst. Evol. Microbiol. 55(Pt 1) , 257-62, (2005) A 4-phenyl-3-butenoic acid-producing actinomycete, designated strain VK-A60T, was isolated from a soil sample collected from Koyang, Korea. Morphological and chemical characteristics of the strain were consistent with those of the genus Streptomyces. The cell... |