HATU
HATU structure
|
Common Name | HATU | ||
|---|---|---|---|---|
| CAS Number | 148893-10-1 | Molecular Weight | 380.23000 | |
| Density | N/A | Boiling Point | 176ºC at 760mmHg | |
| Molecular Formula | C10H15F6N6OP | Melting Point | 183-188 °C (dec.) | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS02, GHS07 |
Signal Word | Danger | |
|
Antisense Oligonucleotide-mediated Suppression of Muscle Glycogen Synthase 1 Synthesis as an Approach for Substrate Reduction Therapy of Pompe Disease.
Mol. Ther. Nucleic Acids 3 , e206, (2014) Pompe disease is an autosomal recessive disorder caused by a deficiency of acid α-glucosidase (GAA; EC 3.2.1.20) and the resultant progressive lysosomal accumulation of glycogen in skeletal and cardiac muscles. Enzyme replacement therapy using recombinant hum... |
|
|
Mixed alkyl aryl phosphonate esters as quenched fluorescent activity-based probes for serine proteases.
Org. Biomol. Chem. 13(8) , 2293-9, (2015) Activity-based probes (ABPs) are powerful tools for the analysis of active enzyme species in whole proteomes, cells or animals. Quenched fluorescent ABPs (qABPs) can be applied for real time imaging, allowing the visualization of dynamic enzyme activation by ... |
|
|
Amino Acid-Porphyrin Conjugates: Synthesis and Study of their Photophysical and Metal Ion Recognition Properties.
Photochem. Photobiol. 91 , 1348-55, (2015) Synthesis, photophysical and metal ion recognition properties of a series of amino acid-linked free-base and Zn-porphyrin derivatives (5-9) are reported. These porphyrin derivatives showed favorable photophysical properties including high molar extinction coe... |
|
|
Acidosis increases MHC class II-restricted presentation of a protein endowed with a pH-dependent heparan sulfate-binding ability.
J. Immunol. 194(8) , 3601-11, (2015) Heparan sulfate proteoglycans (HSPGs) are ubiquitously expressed molecules that participate in numerous biological processes. We previously showed that HSPGs expressed on the surface of APCs can serve as receptors for a hybrid protein containing an HS ligand ... |
|
|
Position and length of fatty acids strongly affect receptor selectivity pattern of human pancreatic polypeptide analogues.
ChemMedChem 9(11) , 2463-74, (2014) Pancreatic polypeptide (PP) is a satiety-inducing gut hormone targeting predominantly the Y4 receptor within the neuropeptide Y multiligand/multireceptor family. Palmitoylated PP-based ligands have already been reported to exert prolonged satiety-inducing eff... |
|
|
Design and solid phase synthesis of new DOTA conjugated (+)-biotin dimers planned to develop molecular weight-tuned avidin oligomers.
Org. Biomol. Chem. 13(13) , 3988-4001, (2015) Chemical modifications of the biotin carrier in pretargeted avidin–biotin radionuclide therapy may be of paramount importance for tuning the amount of the radioactivity delivered to cancer cells by labelled biotins. We report here the synthesis of a collectio... |
|
|
Unraveling the interplay of backbone rigidity and electron rich side-chains on electron transfer in peptides: the realization of tunable molecular wires.
J. Am. Chem. Soc. 136(35) , 12479-88, (2014) Electrochemical studies are reported on a series of peptides constrained into either a 310-helix (1-6) or β-strand (7-9) conformation, with variable numbers of electron rich alkene containing side chains. Peptides (1 and 2) and (7 and 8) are further constrain... |
|
|
Active immunisation of mice with GnRH lipopeptide vaccine candidates: Importance of T helper or multi-dimer GnRH epitope.
Bioorg. Med. Chem. 22(17) , 4848-54, (2014) Active immunisation against gonadotropin releasing hormone (GnRH) is a potential alternative to surgical castration. This study focused on the development of a GnRH subunit lipopeptide vaccine. A library of vaccine candidates that contained one or more (up to... |
|
|
Chemical synthesis of a polypeptide backbone derived from the primary sequence of the cancer protein NY-ESO-1 enabled by kinetically controlled ligation and pseudoprolines.
Biopolymers 104 , 116-27, (2015) The cancer protein NY-ESO-1 has been shown to be one of the most promising vaccine candidates although little is known about its cellular function. Using a chemical protein strategy, the 180 amino acid polypeptide, tagged with an arginine solubilizing tail, w... |
|
|
Cell-penetrating peptides, targeting the regulation of store-operated channels, slow decay of the progesterone-induced [Ca2+]i signal in human sperm.
Mol. Hum. Reprod. 21 , 563-70, (2015) Previous work has provided evidence for involvement of store-operated channels (SOCs) in [Ca(2+)]i signalling of human sperm, including a contribution to the transient [Ca(2+)]i elevation that occurs upon activation of CatSper, a sperm-specific cation channel... |