Doxapram (hydrochloride hydrate)
Doxapram (hydrochloride hydrate) structure
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Common Name | Doxapram (hydrochloride hydrate) | ||
|---|---|---|---|---|
| CAS Number | 7081-53-0 | Molecular Weight | 432.983 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C24H33ClN2O3 | Melting Point | 217-219° | |
| MSDS | N/A | Flash Point | N/A | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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Doxapram and hypokalaemia in very preterm infants.
Arch. Dis. Child Fetal Neonatal Ed. 98(5) , F416-8, (2013) We observed two preterm infants who developed severe hypokalaemia following doxapram. We therefore wished to review the possible association between doxapram and severe hypokalaemia.A retrospective study of preterm infants born before 32 weeks of gestation an... |
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Respiratory inductive plethysmography as a method for measuring ventilatory parameters in conscious, non-restrained dogs.
J. Pharmacol. Toxicol. Methods 62(1) , 47-53, (2010) Assessing the effects of new chemical entities on respiratory function in animal models is an essential component of preclinical drug safety evaluation. Methods currently available for measuring ventilatory parameters in conscious dogs generally utilize a ple... |
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Acid-sensitive channel inhibition prevents fetal alcohol spectrum disorders cerebellar Purkinje cell loss.
Am. J. Physiol. Regul. Integr. Comp. Physiol. 295(2) , R596-603, (2008) Ethanol is now considered the most common human teratogen. Educational campaigns have not reduced the incidence of ethanol-mediated teratogenesis, leading to a growing interest in the development of therapeutic prevention or mitigation strategies. On the basi... |
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Comparison of the effects of caffeine and doxapram on respiratory and cardiovascular function in foals with induced respiratory acidosis.
Am. J. Vet. Res. 68(12) , 1407-16, (2007) To determine and compare the effects of caffeine and doxapram on cardiorespiratory variables in foals during isoflurane-induced respiratory acidosis.6 clinically normal foals (1 to 3 days old).At intervals of > or = 24 hours, foals received each of 3 IV treat... |
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Evaluation of respiratory function in freely moving Beagle dogs using implanted impedance technology.
J. Pharmacol. Toxicol. Methods 62(2) , 119-26, (2010) The Safety Pharmacology ICH S7A guidelines mandate the preclinical evaluation of drug effects on respiratory function. Chronic measurements of potential drug effects are commonly performed in rodents due to lack of a viable alternative in large animals. Prese... |
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Repeated intravenous doxapram induces phrenic motor facilitation.
Exp. Neurol. 250 , 108-15, (2013) Doxapram is a respiratory stimulant used to treat hypoventilation. Here we investigated whether doxapram could also trigger respiratory neuroplasticity. Specifically, we hypothesized that intermittent delivery of doxapram at low doses would lead to long-lasti... |
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The effects of doxapram on medullary respiratory neurones in brainstem-spinal cord preparations from newborn rats.
Anaesthesia 69(5) , 468-75, (2014) Doxapram is the only dedicated respiratory stimulant used to aid recovery of breathing after major surgery. Doxapram acts on peripheral chemoreceptors and although the central action of doxapram has been suggested, its detailed neuronal mechanism is unknown. ... |
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Dynamic QT/RR relationship of cardiac conduction in premature infants treated with low-dose doxapram hydrochloride.
J. Perinat. Med. 35(4) , 330-3, (2007) Doxapram hydrochloride, a respiratory stimulant, has several undesirable side effects during high-dose administration, including second-degree atrioventricular (AV) block and QT prolongation. In Japan, this drug is contraindicated for newborn infants. Recent ... |
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Glial cells are involved in the exciting effects of doxapram on brainstem slices in vitro.
Cell. Mol. Neurobiol. 30(5) , 667-70, (2010) This study tested whether the glial cells are involved in the exciting effects of doxapram on brainstem slice in vitro. Experiments were performed in brainstem slice preparations from neonatal rats. The medial area of nucleus retrofacialis (mNRF) and the hypo... |
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Managing acute on chronic respiratory failure: a guide to non-invasive ventilation.
Br. J. Hosp. Med. (Lond.) 69(8) , 444-9, (2008) Acute-on-chronic respiratory failure is becoming an increasingly common medical emergency, mostly as a result of exacerbations of chronic obstructive pulmonary disease. It is associated with high mortality rates and so practising the best evidence-based manag... |